2,6‐Difluorobenzamide Inhibitors of Bacterial Cell Division Protein FtsZ: Design, Synthesis, and Structure–Activity Relationships
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700201
Abstract: A wide variety of drug‐resistant microorganisms are continuously emerging, restricting the therapeutic options for common bacterial infections. Antimicrobial agents that were originally potent are now no longer helpful, due to their weak or null activity… read more here.
Keywords: cell division; activity; division protein; bacterial cell ... See more keywords
Preparation of Bacterial Cell-Surface Displayed Semisynthetic Cyclic Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1689-5_11
Abstract: Semisynthetic cyclic peptides bearing both non-proteinogenic and genetically encoded amino acids are excellent ligands for peptide-based drug discovery. While semisynthesis expands the chemical space, genetic encoding allows access to a large library via randomization at… read more here.
Keywords: cyclic peptides; semisynthetic cyclic; cell surface; bacterial cell ... See more keywords
Perspective: challenges and opportunities for the study of cardiolipin, a key player in bacterial cell structure and function
Sign Up to like & getrecommendations! Published in 2018 at "Current Genetics"
DOI: 10.1007/s00294-018-0811-2
Abstract: Cardiolipin (CL) is a key player in bacterial cell biology. CL accumulates at the poles of rod-shaped cells; the polar localization and function of diverse bacterial proteins are CL-dependent. Cardiolipin (CL) is an unusual phospholipid… read more here.
Keywords: key player; bacterial cell; player bacterial; cardiolipin key ... See more keywords
Colorimetric enumeration of bacterial contamination in water based on β-galactosidase gold nanoshell activity.
Sign Up to like & getrecommendations! Published in 2017 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2017.01.006
Abstract: In this study we report a method for the rapid and sensitive estimation of bacterial cell concentration in solution based on a colorimetric enzyme/gold nanoshells conjugate system. The CTAB capped gold nanoshells are electrostatically attracted… read more here.
Keywords: colorimetric enumeration; bacterial cell; galactosidase; gold nanoshells ... See more keywords
Strategic incorporation of fluorine in the drug discovery of new-generation antitubercular agents targeting bacterial cell division protein FtsZ.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of fluorine chemistry"
DOI: 10.1016/j.jfluchem.2016.07.020
Abstract: This article presents an account of our research on the discovery and development of new-generation fluorine-containing antibacterial agents against drug-resistant tuberculosis, targeting FtsZ. FtsZ is an essential protein for bacterial cell division and a highly… read more here.
Keywords: new generation; bacterial cell; drug; discovery ... See more keywords
Rapid purification of bacteriophage endolysin TSPphg and its exogenous treatment could act as an alternative bacterial cell disruption method.
Sign Up to like & getrecommendations! Published in 2018 at "Protein expression and purification"
DOI: 10.1016/j.pep.2018.03.014
Abstract: Bacteriophage endolysins have long been demonstrated to be effective enzybiotics, and have the potential value in the areas of food, agricultural, and industrial science. Traditionally, extraction of recombinant proteins from bacterium E. coli is achieved… read more here.
Keywords: disruption; bacterial cell; treatment; bacteriophage ... See more keywords
Bacterial Cell Mechanics Beyond Peptidoglycan.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in microbiology"
DOI: 10.1016/j.tim.2020.04.013
Abstract: The bacterial cell envelope plays essential roles in controlling cell shape, division, pathogenicity, and resistance against external stresses. In Escherichia coli, peptidoglycan (PG) has long been thought to be the primary component that conveys mechanical… read more here.
Keywords: cell mechanics; bacterial cell; cell; mechanics beyond ... See more keywords
Bacterial cell wall material properties determine E. coli resistance to sonolysis
Sign Up to like & getrecommendations! Published in 2022 at "Ultrasonics Sonochemistry"
DOI: 10.1016/j.ultsonch.2022.105919
Abstract: Highlights • Weakened or absent peptidoglycan enables efficient bacterial sonolysis.• Bacteria without peptidoglycan are as sensitive to sonolysis as lipid vesicles.• Remodeling capsule or outer membrane has no effect on bacterial sonolysis.• Non growing bacteria… read more here.
Keywords: properties determine; wall material; cell wall; bacterial cell ... See more keywords
Bacterial Cell Mechanics.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00346
Abstract: Cellular mechanical properties play an integral role in bacterial survival and adaptation. Historically, the bacterial cell wall and, in particular, the layer of polymeric material called the peptidoglycan were the elements to which cell mechanics… read more here.
Keywords: bacterial cell; biology; mechanics; cell mechanics ... See more keywords
Genetic Determinants of Surface Accessibility in Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00173
Abstract: Bacterial cell walls represent one of the most prominent targets of antibacterial agents. These agents include natural products (e.g., vancomycin) and proteins stemming from the innate immune system (e.g., peptidoglycan-recognition proteins and lysostaphin). Among bacterial… read more here.
Keywords: cell; surface accessibility; accessibility; bacterial cell ... See more keywords
Diffusion NMR and Rheology of a Model Polymer in Bacterial Cell Lysate Crowders.
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c01534
Abstract: The intracellular milieu is crowded and heterogeneous, and this can have profound consequences for biomolecule motions and biochemical kinetics. Macromolecular crowding has been traditionally studied in artificial crowders like Ficoll and dextran or globular proteins… read more here.
Keywords: rheology; bacterial cell; cell lysate; lysate ... See more keywords