Computational Tools for the Multiscale Analysis of Hi-C Data in Bacterial Chromosomes.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1390-0_10
Abstract: Just as in eukaryotes, high-throughput chromosome conformation capture (Hi-C) data have revealed nested organizations of bacterial chromosomes into overlapping interaction domains. In this chapter, we present a multiscale analysis framework aiming at capturing and quantifying… read more here.
Keywords: bacterial chromosomes; analysis; tools multiscale; computational tools ... See more keywords
Enzymatic Supercoiling of Bacterial Chromosomes Facilitates Genome Manipulation
Sign Up to like & getrecommendations! Published in 2022 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.2c00353
Abstract: The physical stability of bacterial chromosomes is important for their in vitro manipulation, while genetic stability is important in vivo. However, extracted naked chromosomes in the open circular form are fragile due to nicks and… read more here.
Keywords: bacterial chromosomes; enzymatic supercoiling; chromosomes facilitates; supercoiling bacterial ... See more keywords