Bacterial-driven inflammation and mutant BRAF expression combine to promote murine colon tumorigenesis that is sensitive to immune checkpoint therapy.
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DOI: 10.1158/2159-8290.cd-20-0770
Abstract: Colorectal cancer (CRC) is multi-faceted with subtypes defined by genetic, histological, and immunologic features which are potentially influenced by inflammation, mutagens, and/or microbiota. CRCs with activating mutations in BRAF are associated with distinct clinical characteristics… read more here.
Keywords: inflammation mutant; murine; bacterial driven; colon ... See more keywords