Mapping bacterial effector arsenals: in vivo and in silico approaches to defining the protein features dictating effector secretion by bacteria.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2020.04.002
Abstract: Many bacterial pathogens rely on dedicated secretion systems to translocate virulence proteins termed 'effectors' into host cells. These effectors engage and manipulate host cellular functions to support bacterial colonization and propagation. The secretion systems are… read more here.
Keywords: secretion; arsenals vivo; bacterial effector; effector arsenals ... See more keywords
Cell-Penetrating Bacterial Effector Proteins: Better Tools than Targets.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2016.08.002
Abstract: Bacterial pathogens have developed intriguing virulence mechanisms, including several sophisticated nanomachines, for injecting effector proteins to manipulate host immune signaling pathways for their own benefit. Therefore, bacterial genomes harbor a wealth of information about how… read more here.
Keywords: bacterial effector; cell penetrating; effector proteins; penetrating bacterial ... See more keywords
Bacterial effector screening reveals RNF214 as a virus restriction factor in mammals
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1013035
Abstract: Arboviruses are arthropod-borne viruses that pose significant threats to human and animal health. Previously, we demonstrated that bacterial effector proteins can serve as molecular tools to identify host immunity factors in insect cells that restrict… read more here.
Keywords: replication; screening reveals; bacterial effector; effector ... See more keywords
Searching for the Bacterial Effector: The Example of the Multi-Skilled Commensal Bacterium Faecalibacterium prausnitzii
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.00346
Abstract: Faecalibacterium prausnitzii represents approximately 5% of the total fecal microbiota in healthy adults being one of the most abundant bacterium in the human intestinal microbiota of healthy adults. Furthermore, this bacterium has been proposed to… read more here.
Keywords: bacterium; faecalibacterium prausnitzii; bacterial effector; searching bacterial ... See more keywords
Bacterial effector kinases and strategies to identify their target host substrates
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1113021
Abstract: Post-translational modifications (PTMs) are critical in regulating protein function by altering chemical characteristics of proteins. Phosphorylation is an integral PTM, catalyzed by kinases and reversibly removed by phosphatases, that modulates many cellular processes in response… read more here.
Keywords: bacterial effector; effector kinases; host; phosphorylation ... See more keywords