A multi-phenotypic imaging screen to identify bacterial effectors by exogenous expression in a HeLa cell line
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Data"
DOI: 10.1038/sdata.2018.81
Abstract: We present a high-content screen (HCS) for the simultaneous analysis of multiple phenotypes in HeLa cells expressing an autophagy reporter (mcherry-LC3) and one of 224 GFP-fused proteins from the Crohn’s Disease (CD)-associated bacterium, Adherent Invasive… read more here.
Keywords: identify bacterial; cell; multi phenotypic; imaging screen ... See more keywords
Intracellular delivery of bacterial effectors for cancer therapy using biodegradable lipid nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d3bm00008g
Abstract: Bacterial effector proteins are virulence factors that are secreted and mediate orthogonal post-translational modifications of proteins that are not found naturally in mammalian systems. They hold great promise for developing biotherapeutics by regulating malignant cell… read more here.
Keywords: lipid nanoparticles; using biodegradable; bacterial effectors; cancer therapy ... See more keywords
The interaction of enteric bacterial effectors with the host engulfment pathway control innate immune responses
Sign Up to like & getrecommendations! Published in 2021 at "Gut Microbes"
DOI: 10.1080/19490976.2021.1991776
Abstract: ABSTRACT Host engulfment protein ELMO1 generates intestinal inflammation following internalization of enteric bacteria. In Shigella, bacterial effector IpgB1 interacts with ELMO1 and promotes bacterial invasion. IpgB1 belongs to the WxxxE effector family, a motif found… read more here.
Keywords: elmo1; wxxxe motif; host engulfment; interaction ... See more keywords
The ever-increasing necessity of mass spectrometry in dissecting protein post-translational modifications catalyzed by bacterial effectors.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular microbiology"
DOI: 10.1111/mmi.15071
Abstract: Protein post-translational modifications (PTMs), such as ADP-ribosylation and phosphorylation, regulate multiple fundamental biological processes in cells. During bacterial infection, effector proteins are delivered into host cells through dedicated bacterial secretion systems and can modulate important… read more here.
Keywords: translational modifications; post translational; protein post; bacterial effectors ... See more keywords
Pathogen effectors: What do they do at plasmodesmata?
Sign Up to like & getrecommendations! Published in 2021 at "Molecular plant pathology"
DOI: 10.1111/mpp.13142
Abstract: Plants perceive an assortment of external cues during their life cycle, including abiotic and biotic stressors. Biotic stress from a variety of pathogens, including viruses, oomycetes, fungi, and bacteria, is considered to be a substantial… read more here.
Keywords: effectors plasmodesmata; cell; plant; pathology ... See more keywords
Dynamic remodeling of host membranes by self-organizing bacterial effectors
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.aay8118
Abstract: Bacterial effectors manipulate membranes Many pathogenic bacteria use molecular syringes to translocate proteins called effectors into the host cell to hijack the cellular machinery for their proliferation. Legionella pneumophila, the causative bacteria of Legionnaires' disease,… read more here.
Keywords: phosphatase; bacterial effectors; host; self organizing ... See more keywords
Phthiocerol Dimycocerosates From Mycobacterium tuberculosis Increase the Membrane Activity of Bacterial Effectors and Host Receptors
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.00420
Abstract: Mycobacterium tuberculosis (Mtb) synthesizes a variety of atypical lipids that are exposed at the cell surface and help the bacterium infect macrophages and escape elimination by the cell's immune responses. In the present study, we… read more here.
Keywords: phthiocerol dimycocerosates; activity; bacterial effectors; cell ... See more keywords
Plasmodesmata-Dependent Intercellular Movement of Bacterial Effectors
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.640277
Abstract: Pathogenic microorganisms deliver protein effectors into host cells to suppress host immune responses. Recent findings reveal that phytopathogens manipulate the function of plant cell-to-cell communication channels known as plasmodesmata (PD) to promote diseases. Several bacterial… read more here.
Keywords: intercellular movement; movement; plant; movement bacterial ... See more keywords