Hybrid thermophilic/mesophilic enzymes reveal a role for conformational disorder in regulation of bacterial Enzyme I.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.05.024
Abstract: Conformational disorder is emerging as an important feature of biopolymers, regulating a vast array of cellular functions, including signaling, phase separation, and enzyme catalysis. Here we combine NMR, crystallography, computer simulations, protein engineering, and functional… read more here.
Keywords: hybrid thermophilic; bacterial enzyme; enzyme; conformational disorder ... See more keywords
The Bacterial Enzyme Cas13 Interferes with Neurite Outgrowth from Cultured Cortical Neurons
Sign Up to like & getrecommendations! Published in 2021 at "Toxins"
DOI: 10.3390/toxins13040262
Abstract: The CRISPR-Cas13 system based on a bacterial enzyme has been explored as a powerful new method for RNA manipulation. Due to the high efficiency and specificity of RNA editing/interference achieved by this system, it is… read more here.
Keywords: cas13; bacterial enzyme; cortical neurons; crispr cas13 ... See more keywords