Functional Annotation of Proteins Encoded by the Minimal Bacterial Genome Based on Secondary Structure Element Alignment.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.8b00262
Abstract: In synthetic biology, one of the key focuses is building a minimal artificial cell which can provide basic chassis for functional study. Recently, the J. Craig Venter Institute published the latest version of the minimal… read more here.
Keywords: structure element; minimal bacterial; secondary structure; bacterial genome ... See more keywords
Bacterial Genome Editing via a Designed Toxin-Antitoxin Cassette.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.6b00287
Abstract: Manipulating the bacterial genomes in an efficient manner is essential to biological and biotechnological research. Here, we reprogrammed the bacterial TA systems as the toxin counter-selectable cassette regulated by an antitoxin switch (TCCRAS) for genetic… read more here.
Keywords: genome editing; cassette; bacterial genome; editing via ... See more keywords
Xenogeneic Silencing and Bacterial Genome Evolution: Mechanisms for DNA Recognition Imply Multifaceted Roles of Xenogeneic Silencers
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msab136
Abstract: Abstract Horizontal gene transfer (HGT) is a major driving force for bacterial evolution. To avoid the deleterious effects due to the unregulated expression of newly acquired foreign genes, bacteria have evolved specific proteins named xenogeneic… read more here.
Keywords: multifaceted roles; dna recognition; evolution; xenogeneic silencers ... See more keywords
Bacterial genome architecture shapes global transcriptional regulation by DNA supercoiling
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz300
Abstract: Abstract DNA supercoiling acts as a global transcriptional regulator in bacteria, that plays an important role in adapting their expression programme to environmental changes, but for which no quantitative or even qualitative regulatory model is… read more here.
Keywords: transcription; global transcriptional; dna; dna supercoiling ... See more keywords
Evaluation of the accuracy of bacterial genome reconstruction with Oxford Nanopore R10.4.1 long-read-only sequencing
Sign Up to like & getrecommendations! Published in 2024 at "Microbial Genomics"
DOI: 10.1101/2024.01.12.575342
Abstract: Whole genome reconstruction of bacterial pathogens has become an import tool for tracking antimicrobial resistance spread, however accurate and complete assemblies have only been achievable using hybrid long and short-read sequencing. We have previously found… read more here.
Keywords: bacterial genome; long read; r10; oxford nanopore ... See more keywords
Principles of bacterial genome organization, a conformational point of view
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Microbiology"
DOI: 10.1111/mmi.15290
Abstract: Bacterial chromosomes are large molecules that need to be highly compacted to fit inside the cells. Chromosome compaction must facilitate and maintain key biological processes such as gene expression and DNA transactions (replication, recombination, repair,… read more here.
Keywords: bacterial genome; genome organization; principles bacterial; organization ... See more keywords
Bacterial genome-wide association studies: exploring the genetic variation underlying bacterial phenotypes
Sign Up to like & getrecommendations! Published in 2025 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.02512-24
Abstract: ABSTRACT With the continuous advancements in high-throughput genome sequencing technologies and the development of innovative bioinformatics tools, bacterial genome-wide association studies (BGWAS) have emerged as a transformative approach for investigating the genetic variations underlying diverse… read more here.
Keywords: bacterial genome; bacterial phenotypes; genome wide; wide association ... See more keywords
DELEAT: gene essentiality prediction and deletion design for bacterial genome reduction
Sign Up to like & getrecommendations! Published in 2021 at "BMC Bioinformatics"
DOI: 10.1186/s12859-021-04348-5
Abstract: Background The study of gene essentiality is fundamental to understand the basic principles of life, as well as for applications in many fields. In recent decades, dozens of sets of essential genes have been determined… read more here.
Keywords: gene essentiality; bacterial genome; gene; essentiality ... See more keywords
Mining the bacterial genome to discover new antimicrobial molecules
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202115409
Abstract: Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics… read more here.
Keywords: bacterial genome; genome discover; medicine; mining bacterial ... See more keywords
Evaluation of the Oral Bacterial Genome and Metabolites in Patients with Wolfram Syndrome
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065596
Abstract: In Wolfram syndrome (WFS), due to the loss of wolframin function, there is increased ER stress and, as a result, progressive neurodegenerative disorders, accompanied by insulin-dependent diabetes. The aim of the study was to evaluate… read more here.
Keywords: wfs patients; bacterial genome; evaluation oral; genome metabolites ... See more keywords