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Published in 2018 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.8b00262
Abstract: In synthetic biology, one of the key focuses is building a minimal artificial cell which can provide basic chassis for functional study. Recently, the J. Craig Venter Institute published the latest version of the minimal…
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Keywords:
structure element;
minimal bacterial;
secondary structure;
bacterial genome ... See more keywords
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Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.6b00287
Abstract: Manipulating the bacterial genomes in an efficient manner is essential to biological and biotechnological research. Here, we reprogrammed the bacterial TA systems as the toxin counter-selectable cassette regulated by an antitoxin switch (TCCRAS) for genetic…
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Keywords:
genome editing;
cassette;
bacterial genome;
editing via ... See more keywords
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Published in 2021 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msab136
Abstract: Abstract Horizontal gene transfer (HGT) is a major driving force for bacterial evolution. To avoid the deleterious effects due to the unregulated expression of newly acquired foreign genes, bacteria have evolved specific proteins named xenogeneic…
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Keywords:
multifaceted roles;
dna recognition;
evolution;
xenogeneic silencers ... See more keywords
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Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz300
Abstract: Abstract DNA supercoiling acts as a global transcriptional regulator in bacteria, that plays an important role in adapting their expression programme to environmental changes, but for which no quantitative or even qualitative regulatory model is…
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Keywords:
transcription;
global transcriptional;
dna;
dna supercoiling ... See more keywords
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Published in 2021 at "BMC Bioinformatics"
DOI: 10.1186/s12859-021-04348-5
Abstract: Background The study of gene essentiality is fundamental to understand the basic principles of life, as well as for applications in many fields. In recent decades, dozens of sets of essential genes have been determined…
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Keywords:
gene essentiality;
bacterial genome;
gene;
essentiality ... See more keywords
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Published in 2021 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202115409
Abstract: Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics…
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Keywords:
bacterial genome;
genome discover;
medicine;
mining bacterial ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065596
Abstract: In Wolfram syndrome (WFS), due to the loss of wolframin function, there is increased ER stress and, as a result, progressive neurodegenerative disorders, accompanied by insulin-dependent diabetes. The aim of the study was to evaluate…
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Keywords:
wfs patients;
bacterial genome;
evaluation oral;
genome metabolites ... See more keywords