Artificial Channels in an Infectious Biofilm Created by Magnetic Nanoparticles Enhanced Bacterial Killing by Antibiotics.
Sign Up to like & getrecommendations! Published in 2019 at "Small"
DOI: 10.1002/smll.201902313
Abstract: The poor penetrability of many biofilms contributes to the recalcitrance of infectious biofilms to antimicrobial treatment. Here, a new application for the use of magnetic nanoparticles in nanomedicine to create artificial channels in infectious biofilms… read more here.
Keywords: infectious biofilm; channels infectious; magnetic nanoparticles; infectious biofilms ... See more keywords
Hydrophobicity Determines the Bacterial Killing Rate of α-Helical Antimicrobial Peptides and Influences the Bacterial Resistance Development.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01238
Abstract: Rapid antimicrobial action is an important advantage of antimicrobial peptides (AMPs) over antibiotics, which is also a reason for AMPs being less likely to induce bacterial resistance. However, the structural parameters and underlying mechanisms affecting… read more here.
Keywords: hydrophobicity; bacterial resistance; bacterial killing; killing rate ... See more keywords
A self-cleaning surface based on UV-activatable, AgCl micropumps for bacterial killing and removal.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01343f
Abstract: We report a self-cleaning, bacterial killing surface by immobilization of AgCl microparticles on a surface, acting as chemical micropumps. The surface shows a high bacterial killing efficacy of attached bacteria and exhibits sustainable removal of… read more here.
Keywords: bacterial killing; self cleaning; surface based; surface ... See more keywords
How neutrophil metabolism affects bacterial killing
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DOI: 10.1098/rsob.220248
Abstract: Neutrophils are front line cells in immunity that quickly recognize and eliminate pathogens, relying mainly on glycolysis to exert their killing functions. Even though investigations into the influence of metabolic pathways in neutrophil function started… read more here.
Keywords: metabolism; bacterial killing; affects bacterial; neutrophil metabolism ... See more keywords
Substantial Impact of Altered Pharmacokinetics in Critically Ill Patients on the Antibacterial Effects of Meropenem Evaluated via the Dynamic Hollow-Fiber Infection Model
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DOI: 10.1128/aac.02642-16
Abstract: ABSTRACT Critically ill patients frequently have substantially altered pharmacokinetics compared to non-critically ill patients. We investigated the impact of pharmacokinetic alterations on bacterial killing and resistance for commonly used meropenem dosing regimens. A Pseudomonas aeruginosa… read more here.
Keywords: ill patients; critically ill; bacterial killing; renal function ... See more keywords
TLR9 Negatively Regulates Intracellular Bacterial Killing by Pyroptosis in Burkholderia pseudomallei-Infected Mouse Macrophage Cell Line (Raw264.7)
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03488-22
Abstract: Surface TLRs have been well established to play an essential role in Burkholderia pseudomallei infection. However, the role of endosomal TLRs has not been elucidated. ABSTRACT Melioidosis is a serious infectious disease caused by Burkholderia… read more here.
Keywords: bacterial killing; pseudomallei; role; pyroptosis ... See more keywords
Activation of a bacterial killing machine
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DOI: 10.1371/journal.pgen.1009261
Abstract: Protein secretion systems are multi-subunit machines located in the cell envelopes of prokaryotes. They provide a fundamental route through which bacteria interact with their surroundings. Outside of the laboratory, bacteria are rarely found in monoculture,… read more here.
Keywords: secretion; genetics; activation bacterial; t6ss ... See more keywords
Extracellular vesicles deliver Mycobacterium RNA to promote host immunity and bacterial killing
Sign Up to like & getrecommendations! Published in 2019 at "EMBO reports"
DOI: 10.15252/embr.201846613
Abstract: Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage‐derived EVs through an… read more here.
Keywords: extracellular vesicles; deliver mycobacterium; vesicles deliver; infected macrophages ... See more keywords
Photocatalytic Cu2WS4 Nanocrystals for Efficient Bacterial Killing and Biofilm Disruption
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s360246
Abstract: Background Bacterial biofilm-related wound infections threaten human health due to the lack of efficient treatments. Therefore, developing a novel strategy for wound infection care is urgently needed. Methods Cube-shaped Cu2WS4 nanocrystals (CWSNs) were successfully prepared… read more here.
Keywords: bacterial killing; nanocrystals efficient; efficient bacterial; biofilm ... See more keywords
Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01675
Abstract: Pseudomonas aeruginosa (P.a) is a pathogen causing significant morbidity and mortality, in particular, in hospital patients undergoing ventilation and in patients with cystic fibrosis. Among the virulence factors secreted or injected into host cells, the… read more here.
Keywords: reactive oxygen; pseudomonas aeruginosa; alveolar macrophage; macrophage activity ... See more keywords
Reaction Kinetic Models of Antibiotic Heteroresistance
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20163965
Abstract: Bacterial heteroresistance (i.e., the co-existence of several subpopulations with different antibiotic susceptibilities) can delay the clearance of bacteria even with long antibiotic exposure. Some proposed mechanisms have been successfully described with mathematical models of drug-target… read more here.
Keywords: heteroresistance; kinetic models; reaction; bacterial killing ... See more keywords