Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900698
Abstract: The mechanism of action of quaternary ammonium compound (QAC) antiseptics has long been assumed to be straightforward membrane disruption, although the process of approaching and entering the membrane has little modeling precedent. Furthermore, questions have… read more here.
Keywords: analysis; destabilization; ammonium compounds; ammonium ... See more keywords
Phase Diagram for a Lysyl‐Phosphatidylglycerol Analogue in Biomimetic Mixed Monolayers with Phosphatidylglycerol: Insights into the Tunable Properties of Bacterial Membranes
Sign Up to like & getrecommendations! Published in 2020 at "Chemphyschem"
DOI: 10.1002/cphc.202000026
Abstract: Abstract Ion pairing between the major phospholipids of the Staphylococcus aureus plasma membrane (phosphatidylglycerol – PG and lysyl‐phosphatidylglycerol – LPG) confers resistance to antimicrobial peptides and other antibiotics. We developed 3adLPG, a stable synthetic analogue… read more here.
Keywords: phosphatidylglycerol; analogue; lysyl phosphatidylglycerol; bacterial membranes ... See more keywords
From plants to antimicrobials: Natural products against bacterial membranes
Sign Up to like & getrecommendations! Published in 2021 at "Phytotherapy Research"
DOI: 10.1002/ptr.7275
Abstract: Bacterial membrane barrier provides a cytoplasmic environment for organelles of bacteria. The membrane is composed of lipid compounds containing phosphatide protein and a minimal amount of sugars, and is responsible for intercellular transfers of chemicals.… read more here.
Keywords: products bacterial; membrane; antimicrobials natural; plants antimicrobials ... See more keywords
Absence of phosphatidylcholine in bacterial membranes facilitates translocation of Sec-dependent β-lactamase AmpC from cytoplasm to periplasm in two Pseudomonas strains.
Sign Up to like & getrecommendations! Published in 2017 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2016.04.010
Abstract: Phosphatidylcholine (PC) is a rare membrane lipid in bacteria but crucial for virulence of various plant and animal pathogens. The pcs- mutant lacking PC in bacterial membranes of Pseudomonas syringae pv. syringae van Hall 1336… read more here.
Keywords: translocation; bacterial membranes; lactamase; ampc ... See more keywords
Dichlorobiphenyls and chlorinated benzoic acids – Emergent soil pollutants in model bacterial membranes. Langmuir monolayer and Grazing Incidence X-ray Diffraction studies
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2020.112997
Abstract: Abstract The multi-decade worldwide application of polychlorinated biphenyls (PCB) leads to the problem of soil pollution. The production and application of PCB was banned, so the gradual decrease of their concentration in the soils was… read more here.
Keywords: model bacterial; incidence ray; ray diffraction; grazing incidence ... See more keywords
The π Configuration of the WWW Motif of a Short Trp-Rich Peptide Is Critical for Targeting Bacterial Membranes, Disrupting Preformed Biofilms, and Killing Methicillin-Resistant Staphylococcus aureus.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00456
Abstract: Tryptophan-rich peptides, being short and suitable for large-scale chemical synthesis, are attractive candidates for developing a new generation of antimicrobials to combat antibiotic-resistant bacteria (superbugs). Although there are numerous pictures of the membrane-bound structure of… read more here.
Keywords: rich peptide; www motif; trp; trp rich ... See more keywords
Aggregated amphiphilic antimicrobial peptides embedded in bacterial membranes.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.0c09931
Abstract: Molecular dynamics (MD) simulations, stochastic optical reconstruction microscopy (STORM) and neutron reflection (NR) are combined to explore how antimicrobial peptides (AMPs) can be designed to promote the formation of nanoaggregates into bacterial membranes and impose… read more here.
Keywords: microscopy; peptides embedded; amphiphilic antimicrobial; aggregated amphiphilic ... See more keywords
Formation and Characterization of Supported Lipid Bilayers Composed of Phosphatidylethanolamine and Phosphatidylglycerol by Vesicle Fusion, a Simple but Relevant Model for Bacterial Membranes
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.9b01075
Abstract: Supported lipid bilayers (SLBs) are simple and robust biomimics with controlled lipid composition that are widely used as models of both mammalian and bacterial membranes. However, the lipids typically used for SLB formation poorly resemble… read more here.
Keywords: phosphatidylethanolamine phosphatidylglycerol; lipid bilayers; formation; supported lipid ... See more keywords
Macromolecular-clustered facial amphiphilic antimicrobials
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07651-7
Abstract: Bacterial infections and antibiotic resistance, particularly by Gram-negative pathogens, have become a global healthcare crisis. We report the design of a class of cationic antimicrobial polymers that cluster local facial amphiphilicity from repeating units to… read more here.
Keywords: amphiphilicity; clustered facial; facial amphiphilicity; macromolecular clustered ... See more keywords
Lipid Transport Across Bacterial Membranes.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-120420-022914
Abstract: The movement of lipids within and between membranes in bacteria is essential for building and maintaining the bacterial cell envelope. Moving lipids to their final destination is often energetically unfavorable and does not readily occur… read more here.
Keywords: across bacterial; bacterial membranes; biology; transport across ... See more keywords
Systematic comparison of unilamellar vesicles reveals that archaeal core lipid membranes are more permeable than bacterial membranes
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Biology"
DOI: 10.1371/journal.pbio.3002048
Abstract: One of the deepest branches in the tree of life separates the Archaea from the Bacteria. These prokaryotic groups have distinct cellular systems including fundamentally different phospholipid membrane bilayers. This dichotomy has been termed the… read more here.
Keywords: core; unilamellar vesicles; bacterial membranes; membrane permeability ... See more keywords