Neuroprotective efficacy of the bacterial metabolite, prodigiosin, against aluminium chloride‐induced neurochemical alternations associated with Alzheimer's disease murine model: Involvement of Nrf2/HO‐1/NF‐κB signaling
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DOI: 10.1002/tox.23718
Abstract: Prodigiosin (PDG) is a bacterial metabolite with numerous biological and pharmaceutical properties. Exposure to aluminium is considered a root etiological factor in the pathological progress of Alzheimer's disease (AD). Here, in this investigation, we explored… read more here.
Keywords: aluminium; aluminium chloride; alzheimer disease; pdg ... See more keywords
Optically-controlled bacterial metabolite for cancer therapy
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DOI: 10.1038/s41467-018-03233-9
Abstract: Bacteria preferentially accumulating in tumor microenvironments can be utilized as natural vehicles for tumor targeting. However, neither current chemical nor genetic approaches alone can fully satisfy the requirements on both stability and high efficiency. Here,… read more here.
Keywords: metabolite therapy; controlled bacterial; therapy; bacterial metabolite ... See more keywords
Potential binding modes of the gut bacterial metabolite, 5-hydroxyindole, to the intestinal L-type calcium channels and its impact on the microbiota in rats
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DOI: 10.1080/19490976.2022.2154544
Abstract: ABSTRACT Intestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology. Recently, we have identified a gut-bacterial metabolite, namely 5-hydroxyindole, as a potent stimulant of intestinal motility via its modulation of… read more here.
Keywords: gut bacterial; calcium; microbiota; bacterial metabolite ... See more keywords
Butyrate, a Gut Bacterial Metabolite, Lowers Intraocular Pressure in Normotensive But Not in Hypertensive Rats
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DOI: 10.1097/ijg.0000000000001025
Abstract: Background: Accumulating evidence supports a role of gut bacterial metabolites in arterial blood pressure (BP) regulation. Since the mechanisms controlling intraocular pressure (IOP) and BP overlap, we hypothesized that butyrate, a bacterial metabolite, might affect… read more here.
Keywords: intraocular pressure; hypertensive rats; gut bacterial; bacterial metabolite ... See more keywords
Bacterial Metabolite Reuterin Attenuated LPS-Induced Oxidative Stress and Inflammation Response in HD11 Macrophages
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DOI: 10.3390/antiox11091662
Abstract: Reuterin is well-known for its broad-spectrum antimicrobial ability, while the other potential bioactivity is not yet clear. The present study aims to investigate the immunomodulatory activity of reuterin on chicken macrophage HD11 cells for the… read more here.
Keywords: hd11 macrophages; oxidative stress; hd11; bacterial metabolite ... See more keywords