Heterologous Assembly of Pleomorphic Bacterial Microcompartment Shell Architectures Spanning the Nano- to Microscale.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202212065
Abstract: Many bacteria use protein‐based organelles known as bacterial microcompartments (BMCs) to organize and sequester sequential enzymatic reactions. Regardless of their specialized metabolic function, all BMCs are delimited by a shell made of multiple structurally redundant,… read more here.
Keywords: bmc; pleomorphic bacterial; bacterial microcompartment; assembly pleomorphic ... See more keywords
Recent structural insights into bacterial microcompartment shells.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in microbiology"
DOI: 10.1016/j.mib.2021.04.007
Abstract: Bacterial microcompartments are organelle-like structures that enhance a variety of metabolic functions in diverse bacteria. Composed entirely of proteins, thousands of homologous hexameric shell proteins tesselate to form facets while pentameric proteins form the vertices… read more here.
Keywords: shell proteins; bacterial microcompartment; recent structural; microcompartment shells ... See more keywords
A designed bacterial microcompartment shell with tunable composition and precision cargo loading.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2019.04.011
Abstract: Microbes often augment their metabolism by conditionally constructing proteinaceous organelles, known as bacterial microcompartments (BMCs), that encapsulate enzymes to degrade organic compounds or assimilate CO2. BMCs self-assemble and are spatially delimited by a semi-permeable shell… read more here.
Keywords: designed bacterial; bacterial microcompartment; microcompartment shell; shell ... See more keywords
In Vitro Assembly of Diverse Bacterial Microcompartment Shell Architectures.
Sign Up to like & getrecommendations! Published in 2018 at "Nano letters"
DOI: 10.1021/acs.nanolett.8b02991
Abstract: Bacterial microcompartments (BMCs) are organelles composed of a selectively permeable protein shell that encapsulates enzymes involved in CO2 fixation (carboxysomes) or carbon catabolism (metabolosomes). Confinement of sequential reactions by the BMC shell presumably increases the… read more here.
Keywords: diverse bacterial; vitro assembly; bacterial microcompartment; assembly diverse ... See more keywords
Toward a glycyl radical enzyme containing synthetic bacterial microcompartment to produce pyruvate from formate and acetate
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116871119
Abstract: Significance The enormous complexity of metabolic pathways, in both their regulation and propensity for metabolite cross-talk, represents a major obstacle for metabolic engineering. Self-assembling, catalytically programmable and genetically transferable bacterial microcompartments (BMCs) offer solutions to… read more here.
Keywords: bacterial microcompartment; formate; enzyme; pyruvate ... See more keywords
A synthetic bacterial microcompartment as production platform for pyruvate from formate and acetate
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201330119
Abstract: Bacteria do not have organelles. This textbook statement is as simple as it is false. An organelle is defined as a specialized structure inside a cell that has specific functions, such as the mitochondrium, the… read more here.
Keywords: synthetic bacterial; production platform; pyruvate formate; platform pyruvate ... See more keywords
The potential of bacterial microcompartment architectures for phytonanotechnology.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental microbiology reports"
DOI: 10.1111/1758-2229.13104
Abstract: The application of nanotechnology to plants, termed phytonanotechnology, has the potential to revolutionize plant research and agricultural production. Advancements in phytonanotechnology will allow for the time-controlled and target-specific release of bioactive compounds and agrochemicals to… read more here.
Keywords: bacterial microcompartment; phytonanotechnology potential; microcompartment; architectures phytonanotechnology ... See more keywords
Assembly principles and structure of a 6.5-MDa bacterial microcompartment shell
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aan3289
Abstract: How to make a protein-based nanocontainer Bacterial microcompartments are to bacteria what membrane-bound organelles are to eukaryotic cells. They are specialized subcellular compartments for colocalizing enzymes to enhance reaction rates, protect sensitive proteins, and sequester… read more here.
Keywords: assembly principles; bacterial microcompartment; structure; microcompartment shell ... See more keywords
A Bacterial Microcompartment Is Used for Choline Fermentation by Escherichia coli 536
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Bacteriology"
DOI: 10.1128/jb.00764-17
Abstract: ABSTRACT Bacterial choline degradation in the human gut has been associated with cancer and heart disease. In addition, recent studies found that a bacterial microcompartment is involved in choline utilization by Proteus and Desulfovibrio species.… read more here.
Keywords: bacterial microcompartment; coli 536; choline degradation;
A Survey of Bacterial Microcompartment Distribution in the Human Microbiome
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.669024
Abstract: Bacterial microcompartments (BMCs) are protein-based organelles that expand the metabolic potential of many bacteria by sequestering segments of enzymatic pathways in a selectively permeable protein shell. Sixty-eight different types/subtypes of BMCs have been bioinformatically identified… read more here.
Keywords: microbiome survey; human microbiome; survey; bacterial microcompartment ... See more keywords