Synthesis of Novel Phthalazinedione-Based Derivatives with Promising Cytotoxic, Anti-bacterial, and Molecular Docking Studies as VEGFR2 Inhibitors
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DOI: 10.1021/acsomega.2c03182
Abstract: The parent ester methyl-3-[2-(4-oxo-3-phenyl-3,4-dihydro-phthalazin-1-yloxy)-acetylamino] has 18 compounds. The starting material for alkanoates, their corresponding hydrazides, hydrazones, and dipeptides were produced by chemoselective O-alkylation of 2-phenyl-2,3-dihydrophthalazine-1,4-dione with ethyl chloroacetate(4-oxo-3-phenyl-3,4-dihydro-phthalazin-1-yloxy) acetic acid methyl ester. The starting ester… read more here.
Keywords: molecular docking; anti bacterial; ester; bacterial molecular ... See more keywords
MINFLUX imaging of a bacterial molecular machine at nanometer resolution
Sign Up to like & getrecommendations! Published in 2022 at "Methods and Applications in Fluorescence"
DOI: 10.1088/2050-6120/aca880
Abstract: The resolution achievable with the established super-resolution fluorescence nanoscopy methods, such as STORM or STED, is in general not sufficient to resolve protein complexes or even individual proteins. Recently, minimal photon flux (MINFLUX) nanoscopy has… read more here.
Keywords: minflux; molecular machine; resolution; bacterial molecular ... See more keywords