Mechanistic Insights into the Activities of Major Families of Enzymes in Bacterial Peptidoglycan Assembly and Breakdown
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DOI: 10.1002/cbic.202200693
Abstract: Serving as an exoskeletal scaffold, peptidoglycan is a polymeric macromolecule that is essential and conserved across all bacteria, yet is absent in mammalian cells; this has made bacterial peptidoglycan a well‐established excellent antibiotic target. In… read more here.
Keywords: activities major; bacterial peptidoglycan; assembly breakdown; peptidoglycan assembly ... See more keywords
Carbohydrate recognition and lysis by bacterial peptidoglycan hydrolases.
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DOI: 10.1016/j.sbi.2017.01.001
Abstract: The major component of bacterial cell wall is peptidoglycan (PG), a complex polymer formed by long glycan chains cross-linked by peptide stems. PG is in constant equilibrium requiring well-orchestrated coordination between synthesis and degradation. The… read more here.
Keywords: recognition lysis; carbohydrate recognition; lysis bacterial; biology ... See more keywords
Rational structural modification of the isatin scaffold to develop new and potent antimicrobial agents targeting bacterial peptidoglycan glycosyltransferase
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DOI: 10.1039/d1ra02119b
Abstract: A series of isatin derivatives bearing three different substituent groups at the N-1, C-3 and C-5 positions of the isatin scaffold were systematically designed and synthesized to study the structure–activity relationship of their inhibition of… read more here.
Keywords: bacterial peptidoglycan; peptidoglycan glycosyltransferase; isatin scaffold; activity ... See more keywords