Repurposing a bacterial prolidase for organophosphorus hydrolysis: reshaped catalytic cavity switches substrate selectivity.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.27455
Abstract: Enzyme promiscuity is critical to the acquisition of evolutionary plasticity in cells and can be recruited for high-value chemical synthesis or xenobiotic degradation. The molecular determinants of substrate ambiguity are essential to this activity; however,… read more here.
Keywords: substrate selectivity; repurposing bacterial; hydrolysis; bacterial prolidase ... See more keywords