Advancements in the Development of Non‐Nitrogen‐Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance
Sign Up to like & getrecommendations! Published in 2020 at "ChemMedChem"
DOI: 10.1002/cmdc.202000612
Abstract: The prevalence of quaternary ammonium compounds (QACs) as common disinfecting agents for the past century has led bacteria to develop resistance to such compounds. Given the alarming increase in resistant strains, new strategies are required… read more here.
Keywords: non nitrogen; amphiphilic antiseptics; bacterial resistance; resistance ... See more keywords
A systematic synthesis of expert opinion on effective policies to tackle bacterial resistance worldwide
Sign Up to like & getrecommendations! Published in 2023 at "Veterinary Medicine and Science"
DOI: 10.1002/vms3.1127
Abstract: Abstract Actions that are taken to preserve effective antibacterial agents and eliminate transmission of resistant organisms are crucial to prevent a catastrophic postantibiotic era. In this systematic review, we searched and appraised relevant texts and… read more here.
Keywords: expert opinion; resistance worldwide; bacterial resistance; tackle bacterial ... See more keywords
Stability and periodic solutions for a model of bacterial resistance to antibiotics caused by mutations and plasmids
Sign Up to like & getrecommendations! Published in 2019 at "Applied Mathematical Modelling"
DOI: 10.1016/j.apm.2019.06.017
Abstract: Abstract Bacterial resistance is one of the most prominent public health problems affecting the entire world population. Although some infectious diseases are no longer a problem as they were in the past, the acquisition of… read more here.
Keywords: stability periodic; bacterial resistance; resistant bacteria; resistance ... See more keywords
Towards a Rational Design of Macrolide Antibiotics in Order to Combat Bacterial Resistance
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1749
Abstract: Macrolides, which bind in the protein exit tunnel of the bacterial ribosome, are one of the most prescribed classes of antibiotics.However, macrolide resistance caused by ribosomal modifications at base A2058 in segment 23S is a… read more here.
Keywords: macrolide; bacterial resistance; towards rational; resistance ... See more keywords
Rapid methods for detection of bacterial resistance to antibiotics.
Sign Up to like & getrecommendations! Published in 2017 at "Enfermedades Infecciosas Y Microbiologia Clinica"
DOI: 10.1016/j.eimce.2017.02.007
Abstract: The most widely used antibiotic susceptibility testing methods in Clinical Microbiology are based on the phenotypic detection of antibiotic resistance by measuring bacterial growth in the presence of the antibiotic being tested. These conventional methods… read more here.
Keywords: methods detection; detection; rapid methods; detection bacterial ... See more keywords
A mathematical model for predicting the development of bacterial resistance based on the relationship between the level of antimicrobial resistance and the volume of antibiotic consumption.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2016.11.010
Abstract: OBJECTIVES Infections that are inadequately treated owing to acquired bacterial resistance are a leading cause of mortality. Rates of multidrug-resistant bacteria are rising, resulting in increased antibiotic failures and worsening patient outcomes. Mathematical modelling makes… read more here.
Keywords: bacterial resistance; model; antimicrobial resistance; resistance ... See more keywords
Bacterial resistance to antibodies: a model evolutionary study.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2017.01.022
Abstract: The tangled nature model of evolution (reviewed in the main text) is adapted for use in the study of antibody resistance acquired by horizontal gene transfer. Exchanges of DNA and the acquisition of resistant gene… read more here.
Keywords: resistance antibodies; antibodies model; model evolutionary; bacterial resistance ... See more keywords
Smart Multifunctional Polymer Systems as Alternatives or Supplements of Antibiotics To Overcome Bacterial Resistance.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.1c01614
Abstract: In recent years, infectious diseases have again become a critical threat to global public health largely due to the challenges posed by antimicrobial resistance. Conventional antibiotics have played a crucial role in combating bacterial infections;… read more here.
Keywords: systems alternatives; multifunctional polymer; bacterial resistance; polymer systems ... See more keywords
Hydrophobicity Determines the Bacterial Killing Rate of α-Helical Antimicrobial Peptides and Influences the Bacterial Resistance Development.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01238
Abstract: Rapid antimicrobial action is an important advantage of antimicrobial peptides (AMPs) over antibiotics, which is also a reason for AMPs being less likely to induce bacterial resistance. However, the structural parameters and underlying mechanisms affecting… read more here.
Keywords: hydrophobicity; bacterial resistance; bacterial killing; killing rate ... See more keywords
Defeating Bacterial Resistance and Preventing Mammalian Cells Toxicity Through Rational Design of Antibiotic-Functionalized Nanoparticles
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01209-1
Abstract: The rational synthesis of alternative materials is highly demanding due to the outbreak of infectious diseases and resistance to antibiotics. Herein, we report a tailored nanoantibiotic synthesis protocol where the antibiotic binding was optimized on… read more here.
Keywords: defeating bacterial; resistance preventing; bacterial resistance; preventing mammalian ... See more keywords
Bacterial Resistance in Surgical Infections in Low-Resource Settings.
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DOI: 10.1089/sur.2020.034
Abstract: Background: There is an alarming increase in antimicrobial resistance (AMR) globally, complicating management of surgical infections, especially in low-resource settings. Of particular concern for surgeons are third generation cephalosporin-resistant and carbapenem-resistant Enterobacteriaceae. Methods: The published… read more here.
Keywords: resource settings; bacterial resistance; surgical infections; resistance ... See more keywords