Multivalent Inhibitors of Channel-Forming Bacterial Toxins.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2016_20
Abstract: Rational design of multivalent molecules represents a remarkable modern tool to transform weak non-covalent interactions into strong binding by creating multiple finely-tuned points of contact between multivalent ligands and their supposed multivalent targets. Here, we… read more here.
Keywords: multivalent inhibitors; inhibitors channel; channel forming; bacterial toxins ... See more keywords
Bacterial Toxins Escape the Endosome by Inducing Vesicle Budding and Collapse.
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DOI: 10.1021/acschembio.1c00540
Abstract: Bacterial protein toxins autonomously enter the cytosol of the target cell where they modify the activities of host components to exert their toxic effects. Many of the toxins enter the host cell by endocytosis followed… read more here.
Keywords: endosome inducing; budding collapse; escape endosome; bacterial toxins ... See more keywords
Evolution of insect innate immunity through domestication of bacterial toxins
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2218334120
Abstract: Significance Several disease-causing bacteria produce toxins that damage host cells by triggering preprogrammed cell death. Two such bacterial toxins are called cytolethal distending toxin B and apoptosis-inducing protein of 56 kDa. We discovered that diverse… read more here.
Keywords: immunity domestication; two bacterial; bacterial toxins; innate immunity ... See more keywords
Activation mechanisms of inflammasomes by bacterial toxins
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DOI: 10.1111/cmi.13309
Abstract: Inflammasomes are cytosolic innate immune complexes, which assemble in mammalian cells in response to microbial components and endogenous danger signals. A major family of inflammasome activators is bacterial toxins. Inflammasome sensor proteins, such as the… read more here.
Keywords: mechanisms inflammasomes; family; activation mechanisms; microbiology ... See more keywords
Targeting and inactivation of bacterial toxins by human defensins
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DOI: 10.1515/hsz-2017-0106
Abstract: Abstract Defensins, as a prominent family of antimicrobial peptides (AMP), are major effectors of the innate immunity with a broad range of immune modulatory and antimicrobial activities. In particular, defensins are the only recognized fast-response… read more here.
Keywords: toxins human; inactivation bacterial; targeting inactivation; bacterial toxins ... See more keywords
Bacterial Toxins and Targeted Brain Therapy: New Insights from Cytotoxic Necrotizing Factor 1 (CNF1)
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19061632
Abstract: Pathogenic bacteria produce toxins to promote host invasion and, therefore, their survival. The extreme potency and specificity of these toxins confer to this category of proteins an exceptionally strong potential for therapeutic exploitation. In this… read more here.
Keywords: necrotizing factor; cytotoxic necrotizing; bacterial toxins; factor cnf1 ... See more keywords
Which bacterial toxins are worthy of validation as markers in colorectal cancer screening? A critical review.
Sign Up to like & getrecommendations! Published in 2021 at "Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia"
DOI: 10.5507/bp.2021.054
Abstract: Appropriate screening of early asymptomatic cases can reduce the disease burden and mortality rate of sporadic colorectal cancer (CRC) significantly. Currently, fecal occult blood testing (FOBT) is able to detect up to 80% of asymptomatic… read more here.
Keywords: worthy validation; validation markers; colorectal cancer; toxins worthy ... See more keywords