Repurposing Nitroimidazoles: A New Frontier in Combatting Bacterial Virulence and Quorum Sensing via In Silico, In Vitro, and In Vivo Insights
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development Research"
DOI: 10.1002/ddr.70101
Abstract: The global antibiotic resistance crisis demands innovative strategies targeting bacterial virulence rather than survival. Quorum sensing (QS), a key regulator of virulence and biofilm formation, offers a promising avenue to mitigate resistance by disarming pathogens… read more here.
Keywords: vivo; silico vitro; virulence; repurposing nitroimidazoles ... See more keywords
Evolution of bacterial virulence.
Sign Up to like & getrecommendations! Published in 2017 at "FEMS microbiology reviews"
DOI: 10.1093/femsre/fux023
Abstract: Bacterial virulence is highly dynamic and context-dependent. For this reason, it is challenging to predict how molecular changes affect the growth of a pathogen in a host and its spread in host population. Two schools… read more here.
Keywords: evolution bacterial; virulence; biology; host ... See more keywords
Elicitor-induced plant immunity relies on amino acids accumulation to delay the onset of bacterial virulence.
Sign Up to like & getrecommendations! Published in 2023 at "Plant physiology"
DOI: 10.1093/plphys/kiad048
Abstract: Plant immunity relies on the perception of Microbe-Associate Molecular Patterns (MAMPs) from invading microbes to induce defense responses that suppress attempted infections. It has been proposed that MAMP-triggered immunity (MTI) suppresses bacterial infections by suppressing… read more here.
Keywords: bacterial virulence; amino acids; plant immunity; virulence ... See more keywords
PmiR senses 2-methylisocitrate levels to regulate bacterial virulence in Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.add4220
Abstract: To adapt to changes in environmental cues, Pseudomonas aeruginosa produces an array of virulence factors to survive the host immune responses during infection. Metabolic products contribute to bacterial virulence; however, only a limited number of… read more here.
Keywords: bacterial virulence; pseudomonas aeruginosa; pmir senses; aeruginosa pmir ... See more keywords
Characterization of a metallophosphoesterase that displays phosphatases activity and associated with bacterial virulence from Riemerella anatipestifer.
Sign Up to like & getrecommendations! Published in 2021 at "Applied and environmental microbiology"
DOI: 10.1128/aem.00086-21
Abstract: Riemerella anatipestifer is an important pathogen of waterfowl, causing septicemic and exudative diseases. In our previous study, we demonstrate that bacterial virulence and secretion proteins of the T9SS mutant strains Yb2ΔgldK and Yb2ΔgldM were significantly… read more here.
Keywords: as87 rs00980; bacterial virulence; activity; secretion ... See more keywords
Identification of the BolA Protein Reveals a Novel Virulence Factor in K. pneumoniae That Contributes to Survival in Host
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00378-22
Abstract: BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and affects different pathways directly associated with bacterial virulence. Here, we unraveled the role of BolA in… read more here.
Keywords: bacterial virulence; pneumoniae; bola; virulence ... See more keywords
Characterization of integrated prophages within diverse species of clinical nontuberculous mycobacteria
Sign Up to like & getrecommendations! Published in 2020 at "Virology Journal"
DOI: 10.1186/s12985-020-01394-y
Abstract: Background Nontuberculous mycobacterial (NTM) infections are increasing in prevalence, with current estimates suggesting that over 100,000 people in the United States are affected each year. It is unclear how certain species of mycobacteria transition from… read more here.
Keywords: virulence genes; prophages within; characterization integrated; virulence ... See more keywords
The deletion of HK-1 gene affects the bacterial virulence of Pseudomonas stutzeri LH-42
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0277089
Abstract: Two-component systems (TCSs) are widespread regulatory systems in bacteria, which control cellular functions and play an important role in sensing various external stimuli and regulating gene expression in response to environmental changes. Among the nineteen… read more here.
Keywords: bacterial virulence; pseudomonas stutzeri; deletion; strain ... See more keywords
Bacterial virulence plays a crucial role in MRSA sepsis
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009369
Abstract: Bacterial sepsis is a major global cause of death. However, the pathophysiology of sepsis has remained poorly understood. In industrialized nations, Staphylococcus aureus represents the pathogen most commonly associated with mortality due to sepsis. Because… read more here.
Keywords: sepsis; virulence plays; virulence; mrsa ... See more keywords
In silico Analysis Suggests Common Appearance of scaRNAs in Type II Systems and Their Association With Bacterial Virulence
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00474
Abstract: In addition to its well-established defense function, CRISPR/Cas can also exhibit crucial non-canonical activity through endogenous gene expression regulation, which was found to mainly affect bacterial virulence. These non-canonical functions depend on scaRNA, which is… read more here.
Keywords: type systems; crispr cas; bacterial virulence; crispr ... See more keywords
Exploring the role of bacterial virulence factors and host elements in septic arthritis: insights from animal models for innovative therapies
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2024.1356982
Abstract: Septic arthritis, characterized as one of the most aggressive joint diseases, is primarily attributed to Staphylococcus aureus (S. aureus) and often results from hematogenous dissemination. Even with prompt treatment, septic arthritis frequently inflicts irreversible joint… read more here.
Keywords: host elements; septic arthritis; virulence factors; animal models ... See more keywords