New insights into the codon usage patterns of the bactericidal/permeability-increasing (BPI) gene across nine species.
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DOI: 10.1016/j.gene.2017.03.016
Abstract: Bactericidal/permeability-increasing (BPI) protein is a member of a new generation of proteins known as super-antibiotics that are implicated as endotoxin neutralising agents. Non-uniform usage of synonymous codons for a specific amino acid during translation of… read more here.
Keywords: codon usage; permeability increasing; bpi gene; bactericidal permeability ... See more keywords
Low-Avidity Autoantibodies against Bactericidal/Permeability-Increasing Protein Occur in Gram-Negative and Gram-Positive Bacteremia
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DOI: 10.1128/iai.00444-20
Abstract: Antibody autoreactivity against bactericidal/permeability-increasing protein (BPI) is strongly associated with Pseudomonas aeruginosa infection in cystic fibrosis (CF), non-CF bronchiectasis (BE), and chronic obstructive pulmonary disease (COPD). We examined the pathogen-specific nature of this autoreactivity by… read more here.
Keywords: bactericidal permeability; bacteremia; infection; avidity ... See more keywords
A Polymorphism of Bactericidal/Permeability-Increasing Protein Affects Its Neutralization Efficiency towards Lipopolysaccharide
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DOI: 10.3390/ijms23031324
Abstract: Gram-negative sepsis driven by lipopolysaccharide (LPS) has detrimental outcomes, especially in neonates. The neutrophil-derived bactericidal/permeability-increasing protein (BPI) potently neutralizes LPS. Interestingly, polymorphism of the BPI gene at position 645 (rs4358188) corresponds to a favorable survival… read more here.
Keywords: increasing protein; polymorphism; permeability increasing; bactericidal permeability ... See more keywords
Bactericidal/Permeability-Increasing Protein Downregulates the Inflammatory Response in In Vivo Models of Arthritis
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DOI: 10.3390/ijms232113066
Abstract: We investigated the effects of bactericidal/permeability-increasing protein (BPI) alone or in combination with hyaluronic acid (HA) in two animal models: collagen-induced arthritis (CIA) and crystal-induced inflammation. In CIA, mice were intraperitoneally injected with PBS, HA,… read more here.
Keywords: bpi; increasing protein; permeability increasing; bactericidal permeability ... See more keywords