A Novel PspA Protein Vaccine Intranasal Delivered by Bacterium-Like Particles Provides Broad Protection Against Pneumococcal Pneumonia in Mice
Sign Up to like & getrecommendations! Published in 2018 at "Immunological Investigations"
DOI: 10.1080/08820139.2018.1439505
Abstract: ABSTRACT Background: Streptococcus pneumoniae is a major pathogen accounting for a large number of pneumococcal disease in worldwide. Due to the mucosal immune pathway induces both systemic and mucosal immune responses, the potential strategy to… read more here.
Keywords: protein; protein vaccine; pspa; mucosal ... See more keywords
Vaccine with bacterium‐like particles displaying HIV‐1 gp120 trimer elicits specific mucosal responses and neutralizing antibodies in rhesus macaques
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.14022
Abstract: Preclinical studies have shown that the induction of secretory IgA (sIgA) in mucosa and neutralizing antibodies (NAbs) in sera is essential for designing vaccines that can effectively block the transmission of HIV‐1. We previously showed… read more here.
Keywords: immunization; hiv; neutralizing antibodies; bacterium like ... See more keywords
The adjuvant effect of bacterium-like particles depends on the route of administration
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1082273
Abstract: Direct administration of vaccines to mucosal surfaces, such as via oral or nasal vaccination, represents an attractive alternative, or complement, to current parenteral vaccination because it has a potential to induce antigen-specific immunity both at… read more here.
Keywords: bacterium like; like particles; administration; adjuvant effect ... See more keywords