NGF mediates protection of mesenchymal stem cells-conditioned medium against 2,5-hexanedione-induced apoptosis of VSC4.1 cells via Akt/Bad pathway
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DOI: 10.1007/s11010-020-03727-5
Abstract: It has been shown that the conditioned medium of bone mesenchymal stem cells (BMSC-CM) can inhibit apoptosis of neural cells exposed to 2,5-hexanedione (HD), but its protective mechanism remains unclear. To investigate the underlying mechanism,… read more here.
Keywords: conditioned medium; apoptosis; bad pathway; vsc4 cells ... See more keywords
Expression of the BAD pathway is a marker of triple-negative status and poor outcome
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DOI: 10.1038/s41598-019-53695-0
Abstract: Triple-negative breast cancer (TNBC) has few therapeutic targets, making nonspecific chemotherapy the main treatment. Therapies enhancing cancer cell sensitivity to cytotoxic agents could significantly improve patient outcomes. A BCL2-associated agonist of cell death (BAD) pathway… read more here.
Keywords: status; expression; bad pathway; cancer ... See more keywords
Paeoniflorin protects spiral ganglion neurons from cisplatin‐induced ototoxicity: Possible relation to PINK1/BAD pathway
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DOI: 10.1111/jcmm.14379
Abstract: Abstract The objective of this study was to elucidate whether paeoniflorin (PF) exerted an effect on cisplatin‐induced spiral ganglion neuron (SGN) damage, with special attention given to the role of PINK1/BAD pathway in this process.… read more here.
Keywords: pink1 bad; induced ototoxicity; pathway; spiral ganglion ... See more keywords