Controlling the Regioselectivity of Baeyer–Villiger Monooxygenases by Mutation of Active‐Site Residues
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DOI: 10.1002/cbic.201700223
Abstract: Baeyer–Villiger monooxygenase (BVMO)‐mediated regiodivergent conversions of asymmetric ketones can lead to the formation of “normal” or “abnormal” lactones. In a previous study, we were able to change the regioselectivity of a BVMO by mutation of… read more here.
Keywords: site residues; mutation active; baeyer villiger; regioselectivity ... See more keywords
Discovery and Characterization of a Baeyer‐Villiger Monooxygenase Using Sequence Similarity Network Analysis
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DOI: 10.1002/cbic.202200746
Abstract: Baeyer‐Villiger monooxygenases (BVMOs) are important flavin‐dependent enzymes which perform oxygen insertion reactions leading to valuable products. As reported in many studies, BVMOs are usually unstable during application, preventing a wider usage in biocatalysis. Here, we… read more here.
Keywords: sequence similarity; using sequence; baeyer villiger;
Influence of Hydrophilicity on the Snβ‐Catalyzed Baeyer–Villiger Oxidation of Cyclohexanone with Aqueous Hydrogen Peroxide
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DOI: 10.1002/cctc.201600893
Abstract: Snβ zeolites are amongst the most effective heterogeneous catalysts for the Baeyer–Villiger (BV) oxidation of ketones with aqueous hydrogen peroxide (H2O2). The high selectivity is rooted in the activation of the carbonyl substrate through interaction… read more here.
Keywords: oxidation; baeyer villiger; hydrogen peroxide; aqueous hydrogen ... See more keywords
N‐Hydroxyphthalimide (NHPI) Promoted Aerobic Baeyer‐Villiger Oxidation in the Presence of Aldehydes
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DOI: 10.1002/cctc.201801165
Abstract: Metal‐free aerobic Baeyer‐Villiger (BV) oxidation of ketones to lactones or esters in the presence of aldehydes promoted by N‐hydroxyphthalimide (NHPI) has been developed. The reaction proceeded under mild conditions with excellent selectivity and high yields.… read more here.
Keywords: aerobic baeyer; oxidation; baeyer villiger; hydroxyphthalimide nhpi ... See more keywords
The role of the Baeyer–Villiger reaction in the liquid-phase oxidation of organic compounds
Sign Up to like & getrecommendations! Published in 2018 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-018-2137-0
Abstract: The data on the composition of ester products formed in the Baeyer–Villiger reaction in the liquid-phase oxidation of organic compounds with molecular oxygen, on production channel of peroxy acids, as well as on the influence… read more here.
Keywords: villiger reaction; oxidation; baeyer villiger;
Free available chlorine initiated Baeyer-Villiger oxidation: A key mechanism for chloroform formation during aqueous chlorination of benzophenone UV filters.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental pollution"
DOI: 10.1016/j.envpol.2020.115737
Abstract: Chloroform, a regulated disinfection by-product in water, is often generated during chlorination disinfection treatment. However, the formation of chloroform is heavily dependent on the molecular structures of precursors. Moreover, compounds containing ketone moiety are ubiquitous… read more here.
Keywords: baeyer villiger; chlorination; formation; villiger oxidation ... See more keywords
Baeyer-Villiger monooxygenases from Yarrowia lipolytica catalyze preferentially sulfoxidations.
Sign Up to like & getrecommendations! Published in 2018 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2017.09.008
Abstract: Nine new putative Baeyer-Villiger monooxygenase encoding genes were identified in the eukaryote Yarrowia lipolytica and eight were subsequently cloned and expressed. These enzymes, Yarrowia monooxygenases A-H (YMOA-H), were used in biocatalysis reactions with ketones, sulfides… read more here.
Keywords: baeyer villiger; activity; monooxygenases yarrowia; villiger monooxygenases ... See more keywords
Stereospecific Nitrogen Insertion Using Amino Diphenylphosphinates: An Aza-Baeyer-Villiger Rearrangement.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02361
Abstract: Amino diphenylphosphinates, which are commercially available or easily prepared from hydroxylamine, undergo ring expansion of cyclobutanones toward γ-lactams under mild conditions. A reaction pathway profoundly different from the common Beckmann reaction is achieved through the… read more here.
Keywords: amino diphenylphosphinates; rearrangement; baeyer villiger;
Mutations Increasing Cofactor Affinity, Improve Stability and Activity of a Baeyer–Villiger Monooxygenase
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DOI: 10.1021/acscatal.2c03225
Abstract: The typically low thermodynamic and kinetic stability of enzymes is a bottleneck for their application in industrial synthesis. Baeyer–Villiger monooxygenases, which oxidize ketones to lactones using aerial oxygen, among other activities, suffer particularly from these… read more here.
Keywords: baeyer villiger; affinity; cofactor; activity ... See more keywords
Phosphothreonine (pThr)-Based Multifunctional Peptide Catalysis for Asymmetric Baeyer-Villiger Oxidations of Cyclobutanones.
Sign Up to like & getrecommendations! Published in 2019 at "ACS catalysis"
DOI: 10.1021/acscatal.8b04132
Abstract: Biologically inspired phosphothreonine (pThr)-embedded peptides that function as chiral Brønsted acid catalysts for enantioselective Baeyer-Villiger oxidations (BV) of cyclobutanones with aqueous H2O2 are reported herein. Complementary to traditional BINOL-derived chiral phosphoric acids (CPAs), the functional… read more here.
Keywords: baeyer villiger; pthr based; oxidations cyclobutanones; phosphothreonine pthr ... See more keywords
Microbial-Catalyzed Baeyer–Villiger Oxidation for 3,4-seco-Triterpenoids as Potential HMGB1 Inhibitors
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DOI: 10.1021/acsomega.2c01352
Abstract: Pentacyclic triterpenoids are considered to be the potential HMGB1 inhibitors, but due to the limited number of hydrogen bond donors and the number of rotatable bonds in the rigid skeletons, their further chemical biology research… read more here.
Keywords: catalyzed baeyer; baeyer villiger; hmgb1 inhibitors; hmgb1 ... See more keywords