Abstract PR11: SSX-mediated chromatin engagement and targeting of BAF complexes activates oncogenic transcription in synovial sarcoma
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DOI: 10.1158/1557-3265.sarcomas17-pr11
Abstract: Synovial sarcoma (SS) is a soft-tissue malignancy driven by a recurrent chromosomal translocation (t(X;18)) that uniformly produces the SS18-SSX oncogenic fusion protein. SS18 is a core subunit of the mammalian SWI/SNF (BAF) complexes, which remodel… read more here.
Keywords: baf47; baf complexes; synovial sarcoma; ss18 ssx ... See more keywords