The Bartonella autotransporter BafA activates the host VEGF pathway to drive angiogenesis
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DOI: 10.1038/s41467-020-17391-2
Abstract: Pathogenic bacteria of the genus Bartonella can induce vasoproliferative lesions during infection. The underlying mechanisms are unclear, but involve secretion of an unidentified mitogenic factor. Here, we use functional transposon-mutant screening in Bartonella henselae to… read more here.
Keywords: bartonella; angiogenesis; bafa; bartonella autotransporter ... See more keywords
Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling
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DOI: 10.1042/bsr20200905
Abstract: Abstract Autophagy is dependent upon lysosomes, which fuse with the autophagosome to complete the autophagic process and whose acidic interior permits the activity of their intraluminal degradative enzymes. Chloroquine (CQ) and bafilomycin A1 (BafA) each… read more here.
Keywords: chloroquine bafilomycin; lysosomal storage; storage disorders; mtorc1 signalling ... See more keywords
The autotransporter BafA contributes to the proangiogenic potential of Bartonella elizabethae
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.13057
Abstract: Bartonella elizabethae is a rat‐borne zoonotic bacterium that causes human infectious endocarditis or neuroretinitis. Recently, a case of bacillary angiomatosis (BA) resulting from this organism was reported, leading to speculation that B. elizabethae may also… read more here.
Keywords: proangiogenic potential; bafa; autotransporter bafa; bartonella elizabethae ... See more keywords
Comparison of Biological Activities of BafA Family Autotransporters within Bartonella Species Derived from Cats and Rodents
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DOI: 10.1128/iai.00186-22
Abstract: Bartonella species are hemotropic, facultative intracellular bacteria, some of which cause zoonoses, that are widely disseminated among many mammals, including humans. During infection in humans, vascular endothelial cells play a crucial role as a replicative… read more here.
Keywords: proliferation; bartonella; humans infection; bafa ... See more keywords
The Passenger Domain of Bartonella bacilliformis BafA Promotes Endothelial Cell Angiogenesis via the VEGF Receptor Signaling Pathway
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DOI: 10.1128/msphere.00081-22
Abstract: Bartonella bacilliformis causes life-threatening bacteremia or dermal eruption known as Carrion’s disease in South America. During infection, B. bacilliformis promotes endothelial cell proliferation and the angiogenic process, but the underlying molecular mechanism has not been… read more here.
Keywords: disease; bartonella; bafa; bartonella bacilliformis ... See more keywords