Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Properties of Rozibafusp alfa, a Bispecific Inhibitor of BAFF and ICOSL: Analyses of Phase 1 Clinical Trials.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2929
Abstract: Rozibafusp alfa (AMG 570) is a first-in-class bispecific IgG2-peptide fusion designed to inhibit inducible T-cell costimulator ligand (ICOSL) and B-cell activating factor (BAFF). The pharmacokinetics (PK) and pharmacodynamics (PD) of rozibafusp alfa were investigated in… read more here.
Keywords: baff; rozibafusp alfa; bispecific; icosl ... See more keywords
A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201746934
Abstract: The TNF family cytokines B‐cell activating factor (BAFF) and a proliferation‐inducing ligand (APRIL) support plasma cell survival. It is known that inhibitors of BAFF only (BAFFR‐Fc) or BAFF and APRIL (TACI‐Fc) administered early enough in… read more here.
Keywords: plasma; taci; plasma cells; baff ... See more keywords
BAFF Blockade Attenuates B Cell MALT Formation in Conditional Nlrc5‐Deficient Mice With Helicobacter felis Infection
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Immunology"
DOI: 10.1002/eji.202451355
Abstract: Helicobacter infection is a key cause of gastric B cell mucosa–associated lymphoid tissue (MALT) lymphoma. This study examined the role of B cell–activating factor (BAFF), a major driver of B cell proliferation and many B… read more here.
Keywords: baff blockade; baff; nlrc5 deficient; cell ... See more keywords
B‐cell activating factor (BAFF), BAFF promoter and BAFF receptor allelic variants in hepatitis C virus related Cryoglobulinemic Vasculitis and Non‐Hodgkin's Lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Hematological Oncology"
DOI: 10.1002/hon.3008
Abstract: Cryoglobulinemic Vasculitis (CV) is an autoimmune/lymphoproliferative disorder associated with HCV infection that in 5%–10% of cases evolves into a B cell Non‐Hodgkin's Lymphoma (NHL). B‐cell activating factor (BAFF) is a key regulator in B‐cell development… read more here.
Keywords: cell; baff; hcv; baff baff ... See more keywords
Exploring the role of BAFF as biomarker in the detection of uveal melanoma metastases
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-021-03555-0
Abstract: While B-cell activating factor (BAFF) was identified to promote the invasion in other malignancies, its role in the progression of uveal melanoma (UM) still remains unexplored. Here, we analysed the serum level of BAFF in… read more here.
Keywords: serum baff; biomarker; uveal melanoma; baff ... See more keywords
Expression of BAFF and BAFF receptors in primary Sjögren’s syndrome patients with ectopic germinal center-like structures
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DOI: 10.1007/s10238-020-00637-0
Abstract: B cell-activating factor (BAFF) is an essential cytokine in primary Sjögren’s syndrome (pSS) physiopathology. It has been reported that pSS patients develop germinal center-like (GC-like) structures in their minor salivary glands (MSGs). BAFF, BAFF-R, TACI,… read more here.
Keywords: gren syndrome; baff baff; like structures; baff ... See more keywords
Hermetic thermal behaviors and specific heat capacities of bis(aminofurazano)furazan and bis(nitrofurazano)furazan
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DOI: 10.1007/s10973-018-7242-7
Abstract: Thermal behaviors of bis(aminofurazano)furazan (BAFF) and bis(nitrofurazano)furazan (BNFF) were studied by the differential scanning calorimetry (DSC) method with a special hermetic high-pressure crucible and compared to that with a common standard Al crucible. The exothermic… read more here.
Keywords: specific heat; heat capacities; furazan; baff ... See more keywords
GYF-21, an epoxide 2‑(2‑phenethyl)‑chromone derivative, suppresses dysfunction of B cells mainly via inhibiting BAFF activated signaling pathways.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2018.12.048
Abstract: Activated B cells targeted to autoantigens proliferate and differentiate into antibody-secreting cells. Overproduced autoantibodies will give rise to autoimmune diseases. In this study, we investigated the inhibitory effects of GYF-21, an epoxide 2‑(2‑phenethyl)‑chromone derivative extracted… read more here.
Keywords: epoxide phenethyl; phenethyl chromone; autoimmune diseases; chromone derivative ... See more keywords
BAFF gene silencing attenuates allergic airway inflammation by promoting the generation of Tregs via activating pro-Treg cytokines.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.117172
Abstract: AIMS Allergic airway inflammation is one of the major pathological events involved in asthma, and dysregulation of regulatory T cells (Treg) plays a crucial role in the development of allergic airway inflammation. Here, we attempted… read more here.
Keywords: allergic airway; pro treg; airway inflammation; generation ... See more keywords
Maternal Serum B Cell activating factor in hypertensive and normotensive pregnancies.
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DOI: 10.1016/j.preghy.2018.05.001
Abstract: OBJECTIVES The objective of this study was the analysis of B-Cell Activating Factor (BAFF) levels in pregnancies affected by PE, and in pregnancies affected by fetal growth restriction without Hypertensive disorders and its possible correlation… read more here.
Keywords: baff; baff levels; cell activating; activating factor ... See more keywords
B-Cell Activating Factor secreted by neutrophils is a critical player in lung inflammation to cigarette smoke exposure
Sign Up to like & getrecommendations! Published in 2021 at "Revue Des Maladies Respiratoires"
DOI: 10.1016/j.rmr.2021.02.034
Abstract: Introduction B cell activating factor (BAFF) is a TNF family cytokine mainly produced by adaptive immune cells in particular B and T lymphocytes. Depending on the context, innate immune cells can also produce BAFF. First… read more here.
Keywords: lung; cigarette smoke; baff; cigarette ... See more keywords