A novel BAFF antagonist, BAFF-Trap, effectively alleviates the disease progression of systemic lupus erythematosus in MRL/lpr mice.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular immunology"
DOI: 10.1016/j.molimm.2020.11.010
Abstract: Abnormal B cells, which produce antibodies against self-antigens, play a key role in the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). B-cell activating factor (BAFF) is closely associated… read more here.
Keywords: baff trap; systemic lupus; lupus erythematosus; mrl lpr ... See more keywords
Therapeutic effects of a novel BAFF blocker on arthritis
Sign Up to like & getrecommendations! Published in 2019 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-019-0051-z
Abstract: B-cell targeted therapy is effective for autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis (RA), although there are setbacks in RA clinical trials. In this study, we designed a novel B-cell activating factor… read more here.
Keywords: baff trap; baff; therapeutic effects; arthritis ... See more keywords