Bafilomycin A1 increases the sensitivity of tongue squamous cell carcinoma cells to cisplatin by inhibiting the lysosomal uptake of platinum ions but not autophagy.
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DOI: 10.1016/j.canlet.2018.03.003
Abstract: The role of autophagy in tongue squamous cell carcinoma (TSCC) cisplatin resistance is unclear. We aimed to identify a possible synergistic effect of autophagy inhibitors and cisplatin in TSCC cells and explore the underlying mechanism.… read more here.
Keywords: tongue squamous; platinum; bafilomycin; tscc ... See more keywords
Lysosomotropic bafilomycin-A1 and ML9 causes cell death without affecting the ROS and ATP level
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DOI: 10.1016/j.freeradbiomed.2018.04.492
Abstract: Bafilomycin-A1 is known for its lysosomal V-ATPase targeting, irrespective of cell types. Recently ML9, prevents store-operated Ca2+ entry, also reported for targeting the lysosomes and causing cell death. However, no study has been performed on… read more here.
Keywords: death; bafilomycin; bafilomycin ml9; ros atp ... See more keywords