Bafilomycin A1 increases the sensitivity of tongue squamous cell carcinoma cells to cisplatin by inhibiting the lysosomal uptake of platinum ions but not autophagy.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.03.003
Abstract: The role of autophagy in tongue squamous cell carcinoma (TSCC) cisplatin resistance is unclear. We aimed to identify a possible synergistic effect of autophagy inhibitors and cisplatin in TSCC cells and explore the underlying mechanism.… read more here.
Keywords: tongue squamous; platinum; bafilomycin; tscc ... See more keywords
Lysosomotropic bafilomycin-A1 and ML9 causes cell death without affecting the ROS and ATP level
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DOI: 10.1016/j.freeradbiomed.2018.04.492
Abstract: Bafilomycin-A1 is known for its lysosomal V-ATPase targeting, irrespective of cell types. Recently ML9, prevents store-operated Ca2+ entry, also reported for targeting the lysosomes and causing cell death. However, no study has been performed on… read more here.
Keywords: death; bafilomycin; bafilomycin ml9; ros atp ... See more keywords
Bafilomycin A1 Molecular Effect on ATPase Activity of Subcellular Fraction of Human Colorectal Cancer and Rat Liver
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DOI: 10.3390/ijms25031657
Abstract: Bafilomycin A1 inhibits V-type H+ ATPases on the molecular level, which acidifies endo-lysosomes. The main objective of the study was to assess the effect of bafilomycin A1 on Ca2+ content, NAADP-induced Ca2+ release, and ATPase… read more here.
Keywords: cancer; effect; bafilomycin; atpase activity ... See more keywords