On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.29925
Abstract: The B-cell CLL 2-associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence… read more here.
Keywords: protein homeostasis; bag3; role; bag ... See more keywords
The co‐chaperone BAG3: Orchestrator of the cellular task force in response to stress
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30212
Abstract: We and other research teams have been conducting studies on BAG3 protein for several years. BAG3 was first described as a co‐chaperone of HSP70 in 1999 (by Takayama et al. DOI: 10.1074/jbc.274.2.781) and its interactions… read more here.
Keywords: cancer; bag3; 1002 jcb; cell ... See more keywords
Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25476
Abstract: Mitochondrial abnormalities impact the development of myofibrillar myopathies. Therefore, understanding the mechanisms underlying the removal of dysfunctional mitochondria from cells is of great importance toward understanding the molecular events involved in the genesis of cardiomyopathy.… read more here.
Keywords: bag3; bag3 mitochondrial; mitochondrial quality; role bag3 ... See more keywords
Thiostrepton degrades mutant p53 by eliciting an autophagic response in SW480 cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26601
Abstract: Mutations in p53 gene are one of the hallmarks of tumor development. Specific targeting of mutant p53 protein has a promising role in cancer therapeutics. Our preliminary observation showed destabilization of mutant p53 protein in… read more here.
Keywords: p53 protein; bag3; treatment; thiostrepton ... See more keywords
Novel BAG3 Variants in African American Patients with Cardiomyopathy: Reduced β-Adrenergic Responsiveness in Excitation-Contraction.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2020.09.009
Abstract: BACKGROUND We reported 3 novel non-synonymous single-nucleotide variants of Bcl2-associated athanogene 3 (BAG3) in African Americans with heart failure (HF) which are associated with 2-fold increase in cardiac events (HF hospitalization, heart transplant or death).… read more here.
Keywords: bag3; bag3 variants; contraction; african american ... See more keywords
Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00827-7
Abstract: SKP1-CUL1-F-box (SCF) ubiquitin ligases play fundamental roles in cellular functions. Typically, substrate phosphorylation is required for SCF recognition and subsequent degradation. However, phospho-dependent substrates remain largely unidentified. Here, using quantitative phoshoproteome approach, we performed a… read more here.
Keywords: bag3; scf substrates; phospho dependent; fbxo22 ... See more keywords
Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc03399d
Abstract: BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been… read more here.
Keywords: first selective; discovery synthesis; bag3; synthesis first ... See more keywords
BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1580096
Abstract: ABSTRACT A major cellular catabolic pathway in neurons is macroautophagy/autophagy, through which misfolded or aggregation-prone proteins are sequestered into autophagosomes that fuse with lysosomes, and are degraded. MAPT (microtubule-associated protein tau) is one of the… read more here.
Keywords: protein; microtubule associated; bag3; synpo synaptopodin ... See more keywords
Metformin rescues muscle function in BAG3 myofibrillar myopathy models
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1833500
Abstract: ABSTRACT Dominant de novo mutations in the co-chaperone BAG3 cause a severe form of myofibrillar myopathy, exhibiting progressive muscle weakness, muscle structural failure, and protein aggregation. To elucidate the mechanism of disease in, and identify… read more here.
Keywords: protein; myofibrillar myopathy; muscle; bag3 ... See more keywords
BAG3 Myopathy Presenting With Prominent Neuropathic Phenotype and No Cardiac or Respiratory Involvement: A Case Report and Literature Review.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Neuromuscular Disease"
DOI: 10.1097/cnd.0000000000000300
Abstract: Bcl-2-associated athanogene 3 (BAG3) myopathy is a rare myofibrillar myopathy characterized by toe walking and clumsiness in the first decade with rapid progression to cardiomyopathy and restrictive lung disease in the second decade. Most patients… read more here.
Keywords: prominent neuropathic; neuropathic phenotype; bag3 myopathy; respiratory involvement ... See more keywords
Critical Role of Viral Protein Hexon in Hypervirulent Fowl Adenovirus Serotype-4-Induced Autophagy by Interaction with BAG3 and Promotion of Viral Replication in LMH Cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00284-23
Abstract: HHS, mainly caused by HPFAdV-4, has caused large economic losses to the stakeholders in recent years. Infection of leghorn male hepatocellular (LMH) cells by HPFAdV-4 induced complete autophagy that is essential for HPFAdV-4 replication. ABSTRACT… read more here.
Keywords: replication; lmh cells; bag3; hpfadv ... See more keywords