Corelating the molecular structure of BAG3 to its oncogenic role
Sign Up to like & getrecommendations! Published in 2024 at "Cell Biology International"
DOI: 10.1002/cbin.12199
Abstract: BAG3 is a multifaceted protein characterised by having WW domain, PXXP motif and BAG domain. This protein gets upregulated during malignant transformation of cells and has been associated with poorer survival of patients. Procancerous activity… read more here.
Keywords: role; corelating molecular; bag domain; bag3 ... See more keywords
On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular biochemistry"
DOI: 10.1002/jcb.29925
Abstract: The B-cell CLL 2-associated athanogene (BAG) protein family in general and BAG3, in particular, are pivotal elements of cellular protein homeostasis, with BAG3 playing a major role in macroautophagy. In particular, in the contexts of senescence… read more here.
Keywords: protein homeostasis; bag3; role; bag ... See more keywords
The co‐chaperone BAG3: Orchestrator of the cellular task force in response to stress
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30212
Abstract: We and other research teams have been conducting studies on BAG3 protein for several years. BAG3 was first described as a co‐chaperone of HSP70 in 1999 (by Takayama et al. DOI: 10.1074/jbc.274.2.781) and its interactions… read more here.
Keywords: cancer; bag3; 1002 jcb; cell ... See more keywords
Evidence for the Role of BAG3 in Mitochondrial Quality Control in Cardiomyocytes
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25476
Abstract: Mitochondrial abnormalities impact the development of myofibrillar myopathies. Therefore, understanding the mechanisms underlying the removal of dysfunctional mitochondria from cells is of great importance toward understanding the molecular events involved in the genesis of cardiomyopathy.… read more here.
Keywords: bag3; bag3 mitochondrial; mitochondrial quality; role bag3 ... See more keywords
Thiostrepton degrades mutant p53 by eliciting an autophagic response in SW480 cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26601
Abstract: Mutations in p53 gene are one of the hallmarks of tumor development. Specific targeting of mutant p53 protein has a promising role in cancer therapeutics. Our preliminary observation showed destabilization of mutant p53 protein in… read more here.
Keywords: p53 protein; bag3; treatment; thiostrepton ... See more keywords
Novel BAG3 Variants in African American Patients with Cardiomyopathy: Reduced β-Adrenergic Responsiveness in Excitation-Contraction.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2020.09.009
Abstract: BACKGROUND We reported 3 novel non-synonymous single-nucleotide variants of Bcl2-associated athanogene 3 (BAG3) in African Americans with heart failure (HF) which are associated with 2-fold increase in cardiac events (HF hospitalization, heart transplant or death).… read more here.
Keywords: bag3; bag3 variants; contraction; african american ... See more keywords
USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Oncogenesis"
DOI: 10.1038/s41389-024-00528-z
Abstract: The regulatory significance of ubiquitin-specific peptidase 32 (USP32) in tumor is significant, nevertheless, the biological roles and regulatory mechanisms of USP32 in non-small cell lung cancer (NSCLC) remain unclear. According to our research, USP32 was… read more here.
Keywords: non small; cell lung; small cell; nsclc ... See more keywords
Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00827-7
Abstract: SKP1-CUL1-F-box (SCF) ubiquitin ligases play fundamental roles in cellular functions. Typically, substrate phosphorylation is required for SCF recognition and subsequent degradation. However, phospho-dependent substrates remain largely unidentified. Here, using quantitative phoshoproteome approach, we performed a… read more here.
Keywords: bag3; scf substrates; phospho dependent; fbxo22 ... See more keywords
Cleavage of Bcl-2-associated athanogene by metacaspase determines plant antiviral immunity
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DOI: 10.1038/s41467-025-64021-w
Abstract: Nucleotide-binding leucine-rich repeat receptors (NLRs) function as core components of innate immunity in both plants and animals. In animals, NLR activation initiates caspase-mediated immune signaling. In contrast, plants lack caspases but instead contain metacaspases (MCAs/MCs),… read more here.
Keywords: immunity; antiviral immunity; associated athanogene; bag3 ... See more keywords
Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc03399d
Abstract: BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been… read more here.
Keywords: first selective; discovery synthesis; bag3; synthesis first ... See more keywords
BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1580096
Abstract: ABSTRACT A major cellular catabolic pathway in neurons is macroautophagy/autophagy, through which misfolded or aggregation-prone proteins are sequestered into autophagosomes that fuse with lysosomes, and are degraded. MAPT (microtubule-associated protein tau) is one of the… read more here.
Keywords: protein; microtubule associated; bag3; synpo synaptopodin ... See more keywords