Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology journal"
DOI: 10.1002/biot.201700425
Abstract: Oxidative stress that naturally accumulates in the endoplasmic reticulum (ER) as a result of mitochondrial energy metabolism and protein synthesis can disturb the ER function. Because ER have a responsibility on the protein synthesis and… read more here.
Keywords: baicalein; antibody; cell cultures; cell ... See more keywords
Rational engineering in Escherichia coli for high‐titer production of baicalein based on genome‐scale target identification
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28087
Abstract: Baicalein is a bioactive flavonoid isolated from the traditional Chinese medicinal plant, Scutellaria baicalensis Georgi. Microbial synthesis of flavonoids has been intensively developed owing to the eco‐friendly nature of the process. However, the titer of… read more here.
Keywords: rational engineering; engineering escherichia; escherichia coli; identification ... See more keywords
Baicalein inhibits acinar‐to‐ductal metaplasia of pancreatic acinal cell AR42J via improving the inflammatory microenvironment
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26293
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers. Recent research has demonstrated that chronic pancreatitis (CP) is associated with an increased risk of PDAC, partly due to acinar‐to‐ductal metaplasia (ADM). Baicalein has… read more here.
Keywords: ductal metaplasia; baicalein; acinar ductal; cell ... See more keywords
Baicalein suppresses HER2-mediated malignant transformation of HER2-overexpressing ovarian cancer cells by downregulating HER2 gene expression.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology"
DOI: 10.1002/tox.23790
Abstract: The upregulation of the HER2 oncogene is associated with a variety of human cancers and is associated with poor prognosis. Baicalein is reported to have anti-tumor activity, but the molecular mechanism of this effect in… read more here.
Keywords: cancer; ovarian cancer; her2; her2 gene ... See more keywords
Inhibiting reactive oxygen species-dependent autophagy enhanced baicalein-induced apoptosis in oral squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Natural Medicines"
DOI: 10.1007/s11418-017-1076-7
Abstract: Autophagy modulation has been considered a potential therapeutic strategy for oral squamous cell carcinoma (OSCC). A previous study confirmed that baicalein might possess significant anti-carcinogenic activity. However, whether baicalein induces autophagy and its role in… read more here.
Keywords: baicalein; apoptosis; oral squamous; dependent autophagy ... See more keywords
Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4/NF-κB and STAT1 pathway
Sign Up to like & getrecommendations! Published in 2021 at "Brain Research"
DOI: 10.1016/j.brainres.2021.147626
Abstract: Microglial polarization mediated neuroinflammation plays an important role in the pathological process of stroke. The aim of this study is to determine whether baicalein indirectly ameliorates neuronal injury through modulating microglial polarization after stroke and… read more here.
Keywords: microglial polarization; baicalein; polarization; pathway ... See more keywords
Antioxidant and antimicrobial polyvinyl alcohol electrospun nanofibers containing baicalein-hydroxypropyl-β-cyclodextrin inclusion complex
Sign Up to like & getrecommendations! Published in 2021 at "Colloids and Surfaces A: Physicochemical and Engineering Aspects"
DOI: 10.1016/j.colsurfa.2021.126135
Abstract: Abstract A novel antioxidant and antibacterial material were prepared by incorporating Baicalein-Hydroxypropyl-β-Cyclodextrin inclusion complex (Ba-IC) into polyvinyl alcohol (PVA) nanofibers (PVA-Ba-IC-NF) via electrospinning method. Herein, PVA was used as the polymeric matrix for the nanofibers.… read more here.
Keywords: hydroxypropyl cyclodextrin; polyvinyl alcohol; cyclodextrin inclusion; baicalein ... See more keywords
Baicalein protects cardiomyocytes from oxidative stress induced programmed necrosis by stabilizing carboxyl terminus of Hsc70-interacting protein.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of cardiology"
DOI: 10.1016/j.ijcard.2020.03.035
Abstract: Cardiomyocyte necrosis has been reported to be a major component in pathogenesis of cardiac diseases. We noticed that baicalein, a kind of principal components in the roots of Scutellaria baicalensis Georgi, exerts cardioprotective effects by… read more here.
Keywords: necrosis; baicalein; ripk3; chip ... See more keywords
Baicalein attenuates neuropathic pain and improves sciatic nerve function recovery in rats with partial sciatic nerve transection
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Chinese Medical Association"
DOI: 10.1016/j.jcma.2018.03.014
Abstract: Background: Modulating the inflammatory response to nerve injury may provide therapeutic opportunities by aborting the neurobiological alterations that support the development of persistent pain. Baicalein, a 12‐lipoxygenase inhibitor, has anti‐inflammation properties. It also demonstrates anti‐inflammatory… read more here.
Keywords: baicalein; nerve function; nerve; sciatic nerve ... See more keywords
Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2021.10.003
Abstract: Baicalein, a major bioactive flavone constituent isolated from Scutellaria baicalensis Georgi, has neuroprotective properties in several neurological disorders. Many studies suggest that oxidative stress plays a central role in the pathogenesis of Parkinson's disease (PD).… read more here.
Keywords: mptp; baicalein; mptp induced; neurotoxicity ... See more keywords
Study effect of Chitosan-nanoparticle encapsulated/loaded Baicalein on allergic Asthma pathology in mouse model
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.04.009
Abstract: Abstract Asthma as chronic airway disease has high prevalence in children and imbalance of Th1/Th2 is a critical mechanism in pathogenesis of the asthma. Baicalein as a cell protective and anti-inflammatory flavonoid may have anti-asthma… read more here.
Keywords: pathology; asthma; chitosan nanoparticle; effect ... See more keywords