Bakuchiol from Psoralea corylifolia L. Ameliorates acute kidney injury and improves survival in experimental polymicrobial sepsis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107000
Abstract: Bakuchiol (BAK) is a prenylated phenolic mono-terpene extracted from the fruit of Psoralea corylifolia L., which exerts a protective effect on organs. However, whether BAK has a protective effect on sepsis-induced acute kidney injury (S-AKI)… read more here.
Keywords: bakuchiol; sepsis; kidney injury; psoralea corylifolia ... See more keywords
Bax and Bak Pores: Are We Closing the Circle?
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2016.11.004
Abstract: Bax and its homolog Bak are key regulators of the mitochondrial pathway of apoptosis. On cell stress Bax and Bak accumulate at distinct foci on the mitochondrial surface where they undergo a conformational change, oligomerize,… read more here.
Keywords: pores closing; closing circle; bak pores; bak ... See more keywords
Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation.
Sign Up to like & getrecommendations! Published in 2022 at "Cell death and differentiation"
DOI: 10.1038/s41418-022-00961-w
Abstract: Pro-apoptotic BAK and BAX are activated by BH3-only proteins to permeabilise the outer mitochondrial membrane. The antibody 7D10 also activates BAK on mitochondria and its epitope has previously been mapped to BAK residues in the… read more here.
Keywords: structure bak; loop; bak; activation ... See more keywords
Structural basis of BAK activation in mitochondrial apoptosis initiation
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DOI: 10.1038/s41467-021-27851-y
Abstract: BCL-2 proteins regulate mitochondrial poration in apoptosis initiation. How the pore-forming BCL-2 Effector BAK is activated remains incompletely understood mechanistically. Here we investigate autoactivation and direct activation by BH3-only proteins, which cooperate to lower BAK… read more here.
Keywords: apoptosis initiation; activation; bak; bak activation ... See more keywords
Lacrimal Gland as a Target Organ for Adenovirus Gene Therapy Encoding Erythropoietin for Dry Eye Induced by Benzalkonium Chloride
Sign Up to like & getrecommendations! Published in 2021 at "Current Eye Research"
DOI: 10.1080/02713683.2021.1893754
Abstract: ABSTRACT Purpose: The aims of this work were a) to describe the histology of the lacrimal gland (LG) and cornea induced by an adenovirus (Ad) vector encoding the human erythropoietin (Epo) gene delivered to the… read more here.
Keywords: hepo; bak; gland; gene ... See more keywords
Benzalkonium Chloride: An Irritant and Sensitizer
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DOI: 10.1097/der.0000000000000316
Abstract: Background Benzalkonium chloride (BAK) is a known irritant, and potentially cross-reacting quaternary ammonium compounds are commonly used as preservatives in personal care products. Objective The aim of the study was to review positive reactions to… read more here.
Keywords: chloride irritant; 615 patients; benzalkonium; benzalkonium chloride ... See more keywords
Anti-apoptotic traits in gingival tissue from patients with severe generalized chronic periodontitis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of investigative and clinical dentistry"
DOI: 10.1111/jicd.12422
Abstract: AIM In the present study, we aimed to evaluate the cytosolic and nuclear-mitochondrial expression of pro-apoptotic and anti-apoptotic markers in gingival tissue from patients with severe generalized chronic periodontitis (sGCP). METHODS Twenty-four patients participated in… read more here.
Keywords: nuclear mitochondrial; gingival tissue; anti apoptotic; bak ... See more keywords
Infrastructural Decay
Sign Up to like & getrecommendations! Published in 2023 at "Cultural Anthropology"
DOI: 10.14506/ca38.1.07
Abstract: A growing ethnographic literature attends to maintenance and repair practices in the face of decay and ruination. This article explores the forms of decay that become an integral part of infrastructure maintenance. In Turkey’s Çoruh… read more here.
Keywords: bak; maintenance; infrastructural decay; bir ... See more keywords
Discovery of bakuchiol as an AIM2 inflammasome activator and cause of hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.2139/ssrn.4145409
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Psoralea corylifolia (P. corylifolia Linn.) is a traditional Chinese medicinal plant that exhibits significant aphrodisiac, diuretic, and anti-rheumatic effects. However, it has been reported to cause hepatic injury, but the precise mechanisms remain… read more here.
Keywords: bak; bakuchiol; cause; aim2 inflammasome ... See more keywords
Evaluation of Care Burden and Quality of Life among Family Caregivers of Patıents with Cancer
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DOI: 10.5222/head.2016.216
Abstract: ** Ö Dedeli, Yrd. Doç. Dr.; S Çınar Pakyüz, Prof Dr. Celal Bayar Üniversitesi Manisa Sağlık Yüksekokulu Yazışma Adresi / Address for Correspondence: Manisa Celal Bayar Üniversitesi Sağlık Bilimleri Fakültesi İstasyon Mevkii 45020 Manisa Tel.:… read more here.
Keywords: alm olduklar; manisa; bak; puan ortalamalar ... See more keywords