Structural basis of BAK activation in mitochondrial apoptosis initiation
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DOI: 10.1038/s41467-021-27851-y
Abstract: BCL-2 proteins regulate mitochondrial poration in apoptosis initiation. How the pore-forming BCL-2 Effector BAK is activated remains incompletely understood mechanistically. Here we investigate autoactivation and direct activation by BH3-only proteins, which cooperate to lower BAK… read more here.
Keywords: apoptosis initiation; activation; bak; bak activation ... See more keywords