Competitive, multi-objective and compartmented Flux Balance Analysis for addressing tissue specific Inborn Errors of Metabolism.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12603
Abstract: The inborn error of metabolism Phenylketonuria (PKU, OMIM 261600) is most often due to inactivation of phenylalanine hydroxylase (PAH), which converts phenylalanine (Phe) into tyrosine (Tyr). The reduced PAH activity increases blood concentration of phenylalanine… read more here.
Keywords: flux balance; brain; pathology; blood ... See more keywords
A systematic approach for finding the objective function and active constraints for dynamic flux balance analysis
Sign Up to like & getrecommendations! Published in 2018 at "Bioprocess and Biosystems Engineering"
DOI: 10.1007/s00449-018-1899-y
Abstract: Dynamic flux balance analysis (DFBA) has become an instrumental modeling tool for describing the dynamic behavior of bioprocesses. DFBA involves the maximization of a biologically meaningful objective subject to kinetic constraints on the rate of… read more here.
Keywords: flux balance; objective function; balance analysis; approach finding ... See more keywords
Understanding regulation in substrate dependent modulation of growth and production of alcohols in Clostridium sporogenes NCIM 2918 through metabolic network reconstruction and flux balance analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Bioresource technology"
DOI: 10.1016/j.biortech.2017.10.080
Abstract: Flux Balance Analysis was performed for Clostridium sporogenes NCIM 2918 grown on sole glucose and glycerol or glucose-glycerol combinations at varied concentrations. During acidogenesis, glucose and glucose-glycerol combinations favored improved growth and butyric acid production.… read more here.
Keywords: flux balance; balance analysis; glycerol; clostridium sporogenes ... See more keywords
Fluorine mass balance analysis of selected environmental samples from Norway.
Sign Up to like & getrecommendations! Published in 2021 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2021.131200
Abstract: The presence of unidentified organofluorine compounds (UOF) has been investigated in recent publication, but their environmental occurrence is still poorly understood. Fluorine mass balance analysis was performed on environmental samples from lake Mjøsa and river… read more here.
Keywords: mass balance; environmental samples; balance analysis; fluorine mass ... See more keywords
Interplay of Shadow Price, Phenotype and Alternative Optimal Solutions in Flux Balance Analysis
Sign Up to like & getrecommendations! Published in 2019 at "IFAC-PapersOnLine"
DOI: 10.1016/j.ifacol.2019.06.040
Abstract: Abstract Genome-scale metabolic network models (GEMs) have been applied successfully in many applications, and one important application is to predict different growth phenotypes in various genetic and environmental conditions. Phenotype phase plane (PhPP) analysis is… read more here.
Keywords: shadow price; phpp analysis; flux balance; analysis ... See more keywords
Flux Balance Analysis for Media Optimization and Genetic Targets to Improve Heterologous Siderophore Production
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101016
Abstract: Summary Siderophores are small molecule metal chelators secreted in sparse quantities by their native microbial hosts but can be engineered for enhanced production from heterologous hosts like Escherichia coli. These molecules have been proved to… read more here.
Keywords: flux balance; production; heterologous siderophore; improve heterologous ... See more keywords
Regulatory dynamic enzyme-cost flux balance analysis: A unifying framework for constraint-based modeling.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2020.110317
Abstract: Integrated modeling of metabolism and gene regulation continues to be a major challenge in computational biology. While there exist approaches like regulatory flux balance analysis (rFBA), dynamic flux balance analysis (dFBA), resource balance analysis (RBA)… read more here.
Keywords: flux balance; balance analysis; biology; dynamic enzyme ... See more keywords
Energy balance analysis of model-scale vessel with open and ducted propeller configuration
Sign Up to like & getrecommendations! Published in 2018 at "Ocean Engineering"
DOI: 10.1016/j.oceaneng.2018.08.047
Abstract: This paper focuses on performance analysis of a model scale vessel equipped with an open versus a ducted propeller in self-propulsion using a control volume analysis of energy, applied on Computational Fluid Dynamics (CFD) results.… read more here.
Keywords: energy; analysis; balance analysis; ducted propeller ... See more keywords
Bridging substrate intake kinetics and bacterial growth phenotypes with flux balance analysis incorporating proteome allocation
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-61174-0
Abstract: Empirical kinetic models such as the Monod equation have been widely applied to relate the cell growth with substrate availability. The Monod equation shares a similar form with the mechanistically-based Michaelis-Menten kinetics for enzymatic processes,… read more here.
Keywords: flux balance; growth phenotypes; balance analysis; proteome allocation ... See more keywords
Harmonic Balance Analysis of Lur’e Oscillator Network With Non-Diffusive Weak Coupling
Sign Up to like & getrecommendations! Published in 2023 at "IEEE Control Systems Letters"
DOI: 10.1109/lcsys.2022.3232408
Abstract: The central pattern generator (CPG) is a group of interconnected neurons, existing in biological systems as a control center for oscillatory behaviors. We propose a new approach based on the multivariable harmonic balance to characterize… read more here.
Keywords: harmonic balance; oscillation profile; weak coupling; balance analysis ... See more keywords
An Integrative Gene Expression and Mathematical Flux Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/0008-5472.can-19-3588
Abstract: An integrative bioinformatics, flux balance analysis, and experimental approach identify targetable redox vulnerabilities and show the potential for modulation of cancer antioxidant defense to augment the benefits of existing therapies in melanoma. Melanomas harboring BRAF… read more here.
Keywords: redox vulnerabilities; balance analysis; flux balance; targetable redox ... See more keywords