Walking the Tightrope: Balancing Delicate Inflammation Response to Eradicate Acute Myeloid Leukemia.
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DOI: 10.1158/2159-8290.cd-22-0473
Abstract: Ellegast and colleagues show that monocytic acute myeloid leukemias (AML), enriched in inflammatory and immune gene sets, exploit a transcriptional repressor-namely, IRF2BP2-to mitigate their cell-intrinsic inflammatory output and ensure their maintenance. IRF2BP2 ablation results in… read more here.
Keywords: tightrope balancing; acute; walking tightrope; acute myeloid ... See more keywords