Balancing selection at nonself recognition loci in the chestnut blight fungus, Cryphonectria parasitica, demonstrated by trans-species polymorphisms, positive selection, and even allele frequencies
Sign Up to like & getrecommendations! Published in 2018 at "Heredity"
DOI: 10.1038/s41437-018-0060-7
Abstract: Balancing selection has been inferred in diverse organisms for nonself recognition genes, including those involved in immunity, mating compatibility, and vegetative incompatibility. Although selective forces maintaining polymorphisms are known for genes involved in immunity and… read more here.
Keywords: vegetative incompatibility; nonself recognition; parasitica; balancing selection ... See more keywords
Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09806-6
Abstract: Colour polymorphisms play a key role in sexual selection and speciation, yet the mechanisms that generate and maintain them are not fully understood. Here, we use genomic and transcriptomic tools to identify the precise genetic… read more here.
Keywords: genetics; balancing selection; sex linked; colour polymorphism ... See more keywords
Fitness effects but no temperature-mediated balancing selection at the polymorphic Adh gene of Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1909216116
Abstract: Significance What factors maintain genetic variation in natural populations? Opposing selection pressures on protein stability and catalytic activity are thought to maintain variation along thermal gradients in many enzymes. We examined a classic hypothesis of… read more here.
Keywords: balancing selection; selection; trade; activity ... See more keywords
BetaScan2: Standardized Statistics to Detect Balancing Selection Utilizing Substitution Data
Sign Up to like & getrecommendations! Published in 2020 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evaa013
Abstract: Abstract Long-term balancing selection results in a build-up of alleles at similar frequencies and a deficit of substitutions when compared with an outgroup at a locus. The previously published β(1) statistics detect balancing selection using… read more here.
Keywords: substitution data; balancing selection; selection; standardized statistics ... See more keywords
Balancing Selection Drives the Maintenance of Genetic Variation in Drosophila Antimicrobial Peptides
Sign Up to like & getrecommendations! Published in 2019 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evz191
Abstract: Abstract Genes involved in immune defense against pathogens provide some of the most well-known examples of both directional and balancing selection. Antimicrobial peptides (AMPs) are innate immune effector genes, playing a key role in pathogen… read more here.
Keywords: drosophila; selection drives; drives maintenance; balancing selection ... See more keywords
Studying models of balancing selection using phase-type theory.
Sign Up to like & getrecommendations! Published in 2021 at "Genetics"
DOI: 10.1093/genetics/iyab055
Abstract: Balancing selection (BLS) is the evolutionary force that maintains high levels of genetic variability in many important genes. To further our understanding of its evolutionary significance, we analyse models with BLS acting on a biallelic… read more here.
Keywords: bls; type theory; balancing selection; selection ... See more keywords
Genomic determination of breeding systems and trans-specific evolution of HD MAT genes in suilloid fungi.
Sign Up to like & getrecommendations! Published in 2023 at "Genetics"
DOI: 10.1093/genetics/iyad069
Abstract: Studying the signatures of evolution can help to understand genetic processes. Here we demonstrate how the existence of balancing selection can be used to identify the breeding systems of fungi from genomic data. The breeding… read more here.
Keywords: mat; balancing selection; genealogy; breeding systems ... See more keywords
Selection Balancing at Innate Immune Genes: Adaptive Polymorphism Maintenance in Toll-Like Receptors
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac102
Abstract: Abstract Balancing selection is a classic mechanism for maintaining variability in immune genes involved in host–pathogen interactions. However, it remains unclear how widespread the mechanism is across immune genes other than the major histocompatibility complex… read more here.
Keywords: toll like; immune genes; balancing selection; innate immune ... See more keywords
Genetic analysis of isoform usage in the human anti-viral response reveals influenza-specific regulation of ERAP2 transcripts under balancing selection.
Sign Up to like & getrecommendations! Published in 2018 at "Genome research"
DOI: 10.1101/gr.240390.118
Abstract: While genetic variants are known to be associated with overall gene abundance in stimulated immune cells, less is known about their effects on alternative isoform usage. By analyzing RNA-seq profiles of monocyte-derived dendritic cells from… read more here.
Keywords: erap2; response; balancing selection; gene ... See more keywords
Long-term balancing selection on chromosomal variants associated with crypsis in a stick insect.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular ecology"
DOI: 10.1111/mec.14280
Abstract: How polymorphisms are maintained within populations over long periods of time remains debated, because genetic drift and various forms of selection are expected to reduce variation. Here, we study the genetic architecture and maintenance of… read more here.
Keywords: balancing selection; associated crypsis; chromosomal variants; selection ... See more keywords
Genomics, environment and balancing selection in behaviourally bimodal populations: The caribou case
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Ecology"
DOI: 10.1111/mec.15039
Abstract: Selection forces that favour different phenotypes in different environments can change frequencies of genes between populations along environmental clines. Clines are also compatible with balancing forces, such as negative frequency‐dependent selection (NFDS), which maintains phenotypic… read more here.
Keywords: within populations; balancing selection; selection; selection behaviourally ... See more keywords