2-Methoxyestradiol inhibits carotid artery intimal hyperplasia induced by balloon injury via inhibiting JAK/STAT axis in rats
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DOI: 10.1007/s11356-022-19936-y
Abstract: Intimal hyperplasia (IH) is a common complication of vascular interventional procedures that leads to narrowing of the vessel lumen. 2-Methoxyestradiol (2ME), an estrogen metabolite, has numerous pharmacological actions, including vasoprotective and antiproliferative activities. The present… read more here.
Keywords: balloon injury; intimal hyperplasia; jak stat;
Endothelinergic Contractile Hyperreactivity in Rat Contralateral Carotid to Balloon Injury: Integrated Role for ETB Receptors and Superoxide Anion
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DOI: 10.1155/2017/3137580
Abstract: Temporal consequences of neurocompensation to balloon injury on endothelinergic functionality in rat contralateral carotid were evaluated. Rats underwent balloon injury in left carotid and were treated with CP-96345 (NK1 antagonist). Concentration-response curves for endothelin-1 were… read more here.
Keywords: contralateral carotid; endothelin induced; balloon injury; carotid ... See more keywords
High shear stress attenuated arterial neointimal hyperplasia accompanied by changes in yes-associated protein/jun N-terminal kinase/vascular cell adhesion protein 1 expression
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DOI: 10.1177/17085381211058335
Abstract: Background and objectives Abnormal neointimal hyperplasia (NIH) is known as the predominant mechanism in the pathogenesis of arterial restenosis after balloon angioplasty. Low shear stress (SS) is known to augment balloon injury–induced NIH. The aim… read more here.
Keywords: balloon injury; shear stress; group; protein ... See more keywords