Evaluation of Drug–Drug Interaction Potential between Baloxavir Marboxil and Oseltamivir in Healthy Subjects
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DOI: 10.1007/s40261-018-0697-2
Abstract: Background and ObjectiveBaloxavir marboxil is a prodrug that is metabolized to baloxavir acid, which suppresses viral replication by inhibiting cap-dependent endonuclease with a single oral administration. As the mode of action of baloxavir marboxil is… read more here.
Keywords: administration; drug; baloxavir marboxil; drug drug ... See more keywords
Safety, Tolerability, and Pharmacokinetics of the Novel Anti-influenza Agent Baloxavir Marboxil in Healthy Adults: Phase I Study Findings
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DOI: 10.1007/s40261-018-0710-9
Abstract: Background and ObjectiveBaloxavir marboxil, a prodrug that is metabolized to baloxavir acid, suppresses viral replication by inhibiting cap-dependent endonuclease. This first-in-human phase I study evaluated the safety, tolerability, and pharmacokinetics of baloxavir marboxil/baloxavir acid in… read more here.
Keywords: phase; baloxavir acid; study; baloxavir marboxil ... See more keywords
In vitro characterization of baloxavir acid, a first‐in‐class cap‐dependent endonuclease inhibitor of the influenza virus polymerase PA subunit
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DOI: 10.1016/j.antiviral.2018.10.008
Abstract: ABSTRACT Cap‐dependent endonuclease (CEN) resides in the PA subunit of the influenza virus and mediates the critical “cap‐snatching” step of viral RNA transcription, which is considered to be a promising anti‐influenza target. Here, we describe… read more here.
Keywords: bxa; inhibitor; baloxavir acid; vitro characterization ... See more keywords
Influenza A(H1N1)pdm09 virus exhibiting reduced susceptibility to baloxavir due to a PA E23K substitution detected from a child without baloxavir treatment.
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DOI: 10.1016/j.antiviral.2020.104828
Abstract: Human-to-human transmission of PA I38 mutant influenza A(H3N2) viruses with reduced baloxavir susceptibility has been reported in Japan. In December 2019, we detected a PA E23K mutant A(H1N1)pdm09 virus from a child without baloxavir treatment.… read more here.
Keywords: susceptibility; h1n1 pdm09; influenza; pdm09 virus ... See more keywords
Detection of baloxavir resistant influenza A viruses using next generation sequencing and pyrosequencing methods
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DOI: 10.1016/j.antiviral.2020.104906
Abstract: Abstract Baloxavir, a new antiviral drug targeting cap-dependent endonuclease activity of polymerase acidic (PA) protein of influenza viruses, is now approved in multiple countries. Several substitutions at isoleucine 38 in PA protein (e.g., PA-I38T) have… read more here.
Keywords: influenza viruses; baloxavir resistant; next generation; generation sequencing ... See more keywords
Duration of fever and symptoms in children after treatment with baloxavir marboxil and oseltamivir during the 2018-2019 season and detection of variant influenza a viruses with polymerase acidic subunit substitutions.
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DOI: 10.1016/j.antiviral.2020.104951
Abstract: We conducted a prospective, multicenter, non-randomized observational study to assess the duration of fever and symptoms of influenza A/H1N1pdm09 and A/H3N2 infected children read more here.
Keywords: duration fever; fever symptoms; treatment; baloxavir ... See more keywords
Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2018-2020.
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DOI: 10.1016/j.antiviral.2022.105281
Abstract: Global analysis of the susceptibility of influenza viruses to neuraminidase (NA) inhibitors (NAIs) and the polymerase acidic (PA) inhibitor (PAI) baloxavir was conducted by five World Health Organization Collaborating Centres for Reference and Research on… read more here.
Keywords: neuraminidase inhibitors; viruses neuraminidase; susceptibility; inhibitor ... See more keywords
Influenza A variants with reduced susceptibility to baloxavir isolated from Japanese patients are fit and transmit through respiratory droplets
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DOI: 10.1038/s41564-019-0609-0
Abstract: Here we report the isolation of the influenza A/H1N1 2009 pandemic (A/H1N1pdm) and A/H3N2 viruses carrying an I38T mutation in the polymerase acidic protein—a mutation that confers reduced susceptibility to baloxavir marboxil—from patients before and… read more here.
Keywords: respiratory droplets; japanese patients; isolated japanese; susceptibility baloxavir ... See more keywords
Pharmacokinetics, safety and simulated efficacy of an influenza treatment, baloxavir marboxil, in Chinese individuals.
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DOI: 10.1111/cts.13237
Abstract: Baloxavir marboxil is an endonuclease inhibitor indicated for the treatment of influenza in patients ≥12 years. No data exist for Chinese patients in global studies. This randomized, open-label, phase I study evaluated the pharmacokinetics (PK) and… read more here.
Keywords: baloxavir marboxil; chinese patients; baloxavir; pharmacokinetics safety ... See more keywords
Pleiotropic Effects of Influenza H1, H3, and B Baloxavir-Resistant Substitutions on Replication, Sensitivity to Baloxavir, and Interferon Expression
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DOI: 10.1128/aac.00009-22
Abstract: Baloxavir is an anti-influenza endonuclease inhibitor that targets the polymerase acidic (PA) protein of influenza A and B viruses. Our knowledge regarding the pleiotropic effects of baloxavir resistance-associated substitutions is limited. ABSTRACT Baloxavir is an… read more here.
Keywords: sensitivity; replication; baloxavir; expression ... See more keywords
Baloxavir Marboxil: The First Cap-Dependent Endonuclease Inhibitor for the Treatment of Influenza
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DOI: 10.1177/1060028019826565
Abstract: Objective: To review the pharmacology, pharmacokinetics, clinical trials, and clinical implications of baloxavir marboxil. Data Sources: A MEDLINE search was conducted using the terms baloxavir, baloxavir marboxil, cap-dependent endonuclease inhibitor, and polymerase acidic endonuclease inhibitor.… read more here.
Keywords: baloxavir; dependent endonuclease; baloxavir marboxil; endonuclease inhibitor ... See more keywords