Safety, Tolerability, and Pharmacokinetics of the Novel Anti-influenza Agent Baloxavir Marboxil in Healthy Adults: Phase I Study Findings
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DOI: 10.1007/s40261-018-0710-9
Abstract: Background and ObjectiveBaloxavir marboxil, a prodrug that is metabolized to baloxavir acid, suppresses viral replication by inhibiting cap-dependent endonuclease. This first-in-human phase I study evaluated the safety, tolerability, and pharmacokinetics of baloxavir marboxil/baloxavir acid in… read more here.
Keywords: phase; baloxavir acid; study; baloxavir marboxil ... See more keywords
In vitro characterization of baloxavir acid, a first‐in‐class cap‐dependent endonuclease inhibitor of the influenza virus polymerase PA subunit
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DOI: 10.1016/j.antiviral.2018.10.008
Abstract: ABSTRACT Cap‐dependent endonuclease (CEN) resides in the PA subunit of the influenza virus and mediates the critical “cap‐snatching” step of viral RNA transcription, which is considered to be a promising anti‐influenza target. Here, we describe… read more here.
Keywords: bxa; inhibitor; baloxavir acid; vitro characterization ... See more keywords
Carryover effects of baloxavir acid in human nasopharyngeal/pharyngeal swabs on infectious titer testing of influenza virus
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DOI: 10.1111/irv.12721
Abstract: Baloxavir marboxil (BXM) demonstrated a rapid and profound decline in infectious viral titer 1 day after BXM administration. Rapid reduction in virus titer is a characteristic of BXM. There may be a possibility that drug… read more here.
Keywords: infectious titer; baloxavir acid; carryover effects; titer testing ... See more keywords