Kinetic degradation study for the first licenced anti-influenza polymerase inhibitor, baloxavir marboxil, using HPLC-MS.
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DOI: 10.1002/jssc.202200020
Abstract: The first licensed polymerase inhibitor, baloxavir marboxil was recently approved for the treatment of influenza A and B viruses. Furthermore, there is growing interest in testing the antiviral activity of baloxavir marboxil against Coronavirus. Despite… read more here.
Keywords: inhibitor baloxavir; degradation; polymerase inhibitor; baloxavir marboxil ... See more keywords
Evaluation of Drug–Drug Interaction Potential between Baloxavir Marboxil and Oseltamivir in Healthy Subjects
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DOI: 10.1007/s40261-018-0697-2
Abstract: Background and ObjectiveBaloxavir marboxil is a prodrug that is metabolized to baloxavir acid, which suppresses viral replication by inhibiting cap-dependent endonuclease with a single oral administration. As the mode of action of baloxavir marboxil is… read more here.
Keywords: administration; drug; baloxavir marboxil; drug drug ... See more keywords
Safety, Tolerability, and Pharmacokinetics of the Novel Anti-influenza Agent Baloxavir Marboxil in Healthy Adults: Phase I Study Findings
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DOI: 10.1007/s40261-018-0710-9
Abstract: Background and ObjectiveBaloxavir marboxil, a prodrug that is metabolized to baloxavir acid, suppresses viral replication by inhibiting cap-dependent endonuclease. This first-in-human phase I study evaluated the safety, tolerability, and pharmacokinetics of baloxavir marboxil/baloxavir acid in… read more here.
Keywords: phase; baloxavir acid; study; baloxavir marboxil ... See more keywords
Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil
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DOI: 10.1038/s41598-019-53945-1
Abstract: Baloxavir marboxil (BXM), an antiviral drug for influenza virus, inhibits RNA replication by binding to RNA replication cap-dependent endonuclease (CEN) of influenza A and B viruses. Although this drug was only approved by the FDA… read more here.
Keywords: molecular dynamics; dependent endonuclease; simulation; baloxavir marboxil ... See more keywords
Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection
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DOI: 10.1093/jac/dky462
Abstract: Abstract Objectives Baloxavir marboxil (formerly S-033188) is a first-in-class, orally available, cap-dependent endonuclease inhibitor licensed in Japan and the USA for the treatment of influenza virus infection. We evaluated the efficacy of delayed oral treatment… read more here.
Keywords: influenza virus; baloxavir marboxil; inhibitor; combination ... See more keywords
Pharmacokinetics, safety and simulated efficacy of an influenza treatment, baloxavir marboxil, in Chinese individuals.
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DOI: 10.1111/cts.13237
Abstract: Baloxavir marboxil is an endonuclease inhibitor indicated for the treatment of influenza in patients ≥12 years. No data exist for Chinese patients in global studies. This randomized, open-label, phase I study evaluated the pharmacokinetics (PK) and… read more here.
Keywords: baloxavir marboxil; chinese patients; baloxavir; pharmacokinetics safety ... See more keywords
Effectiveness of baloxavir marboxil against influenza in children
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DOI: 10.1111/ped.13855
Abstract: 1 Hanks S, Coleman K, Reid S et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat. Genet. 2004; 36: 1159–61. 2 Kajii T, Ikeuchi T, Yang Z-Q et al. Cancer-prone… read more here.
Keywords: endocrinology; marboxil influenza; influenza children; baloxavir marboxil ... See more keywords
Baloxavir Marboxil: The First Cap-Dependent Endonuclease Inhibitor for the Treatment of Influenza
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DOI: 10.1177/1060028019826565
Abstract: Objective: To review the pharmacology, pharmacokinetics, clinical trials, and clinical implications of baloxavir marboxil. Data Sources: A MEDLINE search was conducted using the terms baloxavir, baloxavir marboxil, cap-dependent endonuclease inhibitor, and polymerase acidic endonuclease inhibitor.… read more here.
Keywords: baloxavir; dependent endonuclease; baloxavir marboxil; endonuclease inhibitor ... See more keywords