Detection of baloxavir resistant influenza A viruses using next generation sequencing and pyrosequencing methods
Sign Up to like & getrecommendations! Published in 2020 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2020.104906
Abstract: Abstract Baloxavir, a new antiviral drug targeting cap-dependent endonuclease activity of polymerase acidic (PA) protein of influenza viruses, is now approved in multiple countries. Several substitutions at isoleucine 38 in PA protein (e.g., PA-I38T) have… read more here.
Keywords: influenza viruses; baloxavir resistant; next generation; generation sequencing ... See more keywords
Investigating the transmission of baloxavir‐resistant influenza viruses from treated index patients to untreated household contacts in the BLOCKSTONE study
Sign Up to like & getrecommendations! Published in 2023 at "Influenza and Other Respiratory Viruses"
DOI: 10.1111/irv.13079
Abstract: In a post‐hoc analysis of the phase 3 BLOCKSTONE study (JapicCTI‐184180), we investigated household transmission of baloxavir‐resistant (PA/I38X) influenza viruses. Using baloxavir resistance rates from prior clinical trials and the rate of influenza transmission observed… read more here.
Keywords: blockstone study; baloxavir resistant; influenza; transmission ... See more keywords