ATP‐independent assembly machinery of bacterial outer membranes: BAM complex structure and function set the stage for next‐generation therapeutics
Sign Up to like & getrecommendations! Published in 2024 at "Protein Science"
DOI: 10.1002/pro.4896
Abstract: Diderm bacteria employ β‐barrel outer membrane proteins (OMPs) as their first line of communication with their environment. These OMPs are assembled efficiently in the asymmetric outer membrane by the β‐Barrel Assembly Machinery (BAM). The multi‐subunit… read more here.
Keywords: bam complex; next generation; generation therapeutics; outer ... See more keywords
The sacrificial adaptor protein Skp functions to remove stalled substrates from the β-barrel assembly machine
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114997119
Abstract: Significance The outer membrane (OM) of gram-negative bacteria acts as a robust permeability barrier to enable cell survival in a wide variety of harsh environments. Crucial to OM integrity are β-barrel outer membrane proteins (OMPs)… read more here.
Keywords: adaptor protein; sacrificial adaptor; bam complex; barrel ... See more keywords
Bypassing BamD essentiality by mutations in a non-essential substrate
Sign Up to like & getrecommendations! Published in 2025 at "mBio"
DOI: 10.1128/mbio.01769-25
Abstract: ABSTRACT The β-barrel assembly machinery (Bam) is essential for assembling all transmembrane β-barrel outer membrane proteins in gram-negative bacteria. The Bam complex consists of the central β-barrel protein BamA and accessory Bam lipoproteins, including the… read more here.
Keywords: bam complex; bamd essentiality; bamd; omp assembly ... See more keywords