Effects of Periplasmic Chaperones and Membrane Thickness on BamA-Catalyzed Outer-Membrane Protein Folding
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Biology"
DOI: 10.1016/j.jmb.2017.09.008
Abstract: The biogenesis of outer-membrane proteins (OMPs) in gram-negative bacteria involves delivery by periplasmic chaperones to the β-barrel assembly machinery (BAM), which catalyzes OMP insertion into the outer membrane. Here, we examine the effects of membrane… read more here.
Keywords: periplasmic chaperones; barrel; bama; outer membrane ... See more keywords
BamA forms a translocation channel for polypeptide export across the bacterial outer membrane.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.02.023
Abstract: The β-barrel assembly machine (BAM) integrates β-barrel proteins into the outer membrane (OM) of Gram-negative bacteria. An essential BAM subunit (BamA) catalyzes integration by promoting the formation of a hybrid-barrel intermediate state between its own… read more here.
Keywords: polypeptide export; barrel; bama; outer membrane ... See more keywords
The Formation of β-Strand Nine (β9) in the Folding and Insertion of BamA from an Unfolded Form into Lipid Bilayers
Sign Up to like & getrecommendations! Published in 2023 at "Membranes"
DOI: 10.3390/membranes13020247
Abstract: Transmembrane proteins span lipid bilayer membranes and serve essential functions in all living cells. Membrane-inserted domains are of either α-helical or β-barrel structure. Despite their biological importance, the biophysical mechanisms of the folding and insertion… read more here.
Keywords: spectroscopy; form; folding insertion; bama ... See more keywords