Design, synthesis and biological evaluation of bambuterol analogues as novel inhibitors of butyrylcholinesterase.
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DOI: 10.1016/j.ejmech.2016.08.061
Abstract: An increase activity of butyrylcholinesterase is believed to contribute to Alzheimer's disease. Bambuterol is a known potent inhibitor of butyrylcholinesterase, but it has undesired cardiac effects and less lipophilicity. Thirteen bambuterol analogues were synthesized using… read more here.
Keywords: design synthesis; butyrylcholinesterase; bambuterol analogues; biological evaluation ... See more keywords