Familial and Somatic BAP1 Mutations Inactivate ASXL1/2-Mediated Allosteric Regulation of BAP1 Deubiquitinase by Targeting Multiple Independent Domains.
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DOI: 10.1158/0008-5472.can-17-2876
Abstract: Deleterious mutations of the ubiquitin carboxy-terminal hydrolase BAP1 found in cancers are predicted to encode inactive truncated proteins, suggesting that loss of enzyme function is a primary tumorigenic mechanism. However, many tumors exhibit missense mutations… read more here.
Keywords: mutations inactivate; bap1; bap1 asxl2; bap1 mutations ... See more keywords