BAP1 loss confers sensitivity to bromodomain and extra-terminal inhibitors in renal cell carcinoma
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DOI: 10.1097/cad.0000000000001647
Abstract: The tumor suppressor gene BRCA1 associated protein-1 (BAP1) is frequently mutated in renal cell carcinoma (RCC). BAP1 loss-of-function mutations are associated with poor survival outcomes. However, personalized therapy for BAP1-mutated RCC is currently not available.… read more here.
Keywords: loss; rcc; bap1 loss; cell carcinoma ... See more keywords
Tumour Angiogenesis in Uveal Melanoma Is Related to Genetic Evolution
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DOI: 10.3390/cancers11070979
Abstract: Increased angiogenesis is associated with a higher metastasis- and mortality rate in uveal melanoma (UM). Recently, it was demonstrated that genetic events, such as 8q-gain and BAP1-loss, influence the level of immune infiltrate. We aimed… read more here.
Keywords: angiogenesis; mvd; uveal melanoma; expression ... See more keywords
BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in Class 2 Uveal Melanomas
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DOI: 10.3390/cancers14153678
Abstract: Simple Summary Uveal melanoma is a highly metastatic cancer of the eye which is notoriously resistant to therapy. Elucidating the mechanisms of metastasis in order to devise effective therapies has been a major challenge. The… read more here.
Keywords: bap1; class; bap1 loss; tumor ... See more keywords