Modeling Renal Cell Carcinoma in Mice: Bap1 and Pbrm1 Inactivation Drive Tumor Grade.
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DOI: 10.1158/2159-8290.cd-17-0292
Abstract: Clear cell renal cell carcinoma (ccRCC) is characterized by BAP1 and PBRM1 mutations, which are associated with tumors of different grade and prognosis. However, whether BAP1 and PBRM1 loss causes ccRCC and determines tumor grade… read more here.
Keywords: tumor grade; ccrcc; cell; bap1 pbrm1 ... See more keywords
BAP1 and PBRM1 in metastatic clear cell renal cell carcinoma: tumor heterogeneity and concordance with paired primary tumor
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DOI: 10.1186/s12894-017-0209-3
Abstract: BackgroundBAP1 and PBRM1 are frequently mutated in primary clear cell renal cell carcinoma (ccRCC) tumors; however, the frequency and clinical relevance of these mutations in metastatic ccRCC tumors is unknown. Additionally, while intra-tumor heterogeneity has… read more here.
Keywords: pbrm1; expression; bap1 pbrm1; cell ... See more keywords