BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature22798
Abstract: BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that modulates environmental carcinogenesis. All carriers of inherited heterozygous germline BAP1-inactivating mutations (BAP1+/−) developed one and often several BAP1−/− malignancies in their lifetime, mostly malignant… read more here.
Keywords: bap1 regulates; regulates ip3r3; bap1; ca2 flux ... See more keywords
BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aax1738
Abstract: BAP1 regulates developmental switch in lineages commonly affected by BAP1-mutant cancers. The BAP1 tumor suppressor is mutated in many human cancers such as uveal melanoma, leading to poor patient outcome. It remains unclear how BAP1… read more here.
Keywords: mutant cancers; bap1 regulates; bap1; switch ... See more keywords