Neuroprotective Effect of Barbaloin on Streptozotocin-Induced Cognitive Dysfunction in Rats via Inhibiting Cholinergic and Neuroinflammatory Cytokines Pathway—TNF-α/IL-1β/IL-6/NF-κB
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DOI: 10.1021/acsomega.2c08277
Abstract: Streptozotocin (STZ) impairs memory in rats through altering the central nervous systems (CNS) as a result of impaired cholinergic dysfunction, oxidative stress, persistent hyperglycemia, and alterations in the glucagon-like peptide (GLP). In this model cholinergic… read more here.
Keywords: cognitive dysfunction; streptozotocin; caused stz; dysfunction ... See more keywords
Barbaloin Treatment Contributes to the Rebalance of Glucose and Lipid Homeostasis of Gestational Diabetes Mellitus Mice
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DOI: 10.1177/1559325820984910
Abstract: Aloe vera L has been shown to possess hypoglycemic and hypolipidemic effects on type 2 diabetic patients, and its major benefits may be linked to barbaloin, which is a major component of Aloe vera L.… read more here.
Keywords: gestational diabetes; barbaloin treatment; gdm mice; diabetes mellitus ... See more keywords
Mucoadhesive Polymeric Films to Enhance Barbaloin Penetration Into Buccal Mucosa: a Novel Approach to Chemoprevention
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DOI: 10.1208/s12249-018-1202-1
Abstract: Nowadays, chemoprevention by administering natural supplements is considered an attractive strategy to reverse, suppress, or prevent the evolution of premalignant oral lesions. In particular, Barbaloin exhibits anti-proliferative, anti-inflammatory, and anti-cancer properties, and it results useful… read more here.
Keywords: penetration; buccal mucosa; drug; barbaloin penetration ... See more keywords
Barbaloin promotes osteogenic differentiation of human bone marrow mesenchymal stem cells: involvement of Wnt/β-catenin signaling pathway.
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DOI: 10.2174/0929867329666220629150656
Abstract: BACKGROUND Barbaloin, found in Aloe vera, exerts broad pharmacological activities including antioxidant, anti-inflammatory, and anti-cancer. This study aims to investigate the effects of barbaloin on the osteogenic differentiation of human bone marrow mesenchymal stem cells… read more here.
Keywords: hbmscs; wnt catenin; osteogenic differentiation; barbaloin ... See more keywords