Aberrant Zip14 expression in muscle is associated with cachexia in a Bard1‐deficient mouse model of breast cancer metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3242
Abstract: Nearly 80% of advanced cancer patients are afflicted with cachexia, a debilitating syndrome characterized by extensive loss of muscle mass and function. Cachectic cancer patients have a reduced tolerance to antineoplastic therapies and often succumb… read more here.
Keywords: muscle; bard1; breast cancer; model ... See more keywords
p50 mono-ubiquitination and interaction with BARD1 regulates cell cycle progression and maintains genome stability
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DOI: 10.1038/s41467-020-18838-2
Abstract: p50, the mature product of NFKB1, is constitutively produced from its precursor, p105. Here, we identify BARD1 as a p50-interacting factor. p50 directly associates with the BARD1 BRCT domains via a C-terminal phospho-serine motif. This… read more here.
Keywords: mono ubiquitination; p50; bard1; cell cycle ... See more keywords
Up-regulation of BRCA1-associated RING Domain 1 Promotes Hepatocellular Carcinoma Progression by Targeting Akt Signaling
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DOI: 10.1038/s41598-017-07962-7
Abstract: The present study was designed to investigate the potential clinical, pathological, prognostic value, role and mechanism of BRCA1-associated RING Domain 1 (BARD1) in Hepatocellular carcinoma (HCC). Quantitative real-time PCR and immunohistochemistry were performed to evaluate… read more here.
Keywords: associated ring; hcc; bard1; ring domain ... See more keywords
Functional analysis of clinical BARD1 germline variants
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DOI: 10.1101/mcs.a004093
Abstract: Germline pathogenic variants in BRCA1/2 account for one-third of familial breast cancers. The majority of BRCA1 function requires heterodimerization with BARD1. In contrast to BRCA1, BARD1 is a low-penetrance gene with an unclear clinical relevance,… read more here.
Keywords: pathogenic variants; bard1; breast cancers; germline ... See more keywords
Abstract 6001: Epigenetic regulation of BARD1 confers resistance to anti-VEGF therapy in ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6001
Abstract: Introduction: Vascular endothelial growth factor (VEGF) is a key promoter of angiogenesis and disease progression in epithelial ovarian cancer (OC). Bevacizumab, a humanized anti-VEGF monoclonal antibody, is approved for treatment of patients with ovarian and… read more here.
Keywords: ava therapy; anti vegf; therapy; bard1 ... See more keywords
BARD1 is a Low/Moderate Breast Cancer Risk Gene: Evidence Based on an Association Study of the Central European p.Q564X Recurrent Mutation
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DOI: 10.3390/cancers11060740
Abstract: In addition to several well-established breast cancer (BC) susceptibility genes, the contribution of other candidate genes to BC risk remains mostly undefined. BARD1 is a potentially predisposing BC gene, however, the rarity of its mutations… read more here.
Keywords: risk; bard1; study; association ... See more keywords
HuR Plays a Role in Double-Strand Break Repair in Pancreatic Cancer Cells and Regulates Functional BRCA1-Associated-Ring-Domain-1(BARD1) Isoforms
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DOI: 10.3390/cancers14071848
Abstract: Simple Summary RNA binding proteins (RBPs) post-transcriptionally regulate and stabilize a variety of target mRNA transcripts. Human Antigen R (HuR) binds to several pro-survival mRNA transcripts and promotes tumor cell survival and chemotherapeutic resistance. Some… read more here.
Keywords: pdac; associated ring; hur; ring domain ... See more keywords
Differential Expression of BARD1 Isoforms in Melanoma
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DOI: 10.3390/genes12020320
Abstract: Melanoma comprises read more here.
Keywords: expression bard1; splice; bard1 isoforms; differential expression ... See more keywords