Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice
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DOI: 10.1371/journal.pgen.1008424
Abstract: Type 2 diabetes (T2D) has become a major health problem worldwide. Skeletal muscle (SKM) is the key tissue for whole-body glucose disposal and utilization. New drugs aimed at improving insulin sensitivity of SKM would greatly… read more here.
Keywords: skeletal muscle; barr2; barr1 barr2; mice ... See more keywords
1797-P: ß-arrestin-1 in AgRP Neurons Plays Crucial Role in Maintaining Whole Body Glucose Homeostasis
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DOI: 10.2337/db19-1797-p
Abstract: Hunger and satiety are regulated, to a major extent, by the agouti-related protein (AgRP)/neuropeptide Y (NPY) and proopiomelanocortin (POMC) neurons residing in the arcuate nucleus of the hypothalamus. During starvation, AgRP neurons are strongly activated… read more here.
Keywords: none; homeostasis; agrp neurons; activity agrp ... See more keywords