β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14295
Abstract: β-arrestins are critical signalling molecules that regulate many fundamental physiological functions including the maintenance of euglycemia and peripheral insulin sensitivity. Here we show that inactivation of the β-arrestin-2 gene, barr2, in β-cells of adult mice… read more here.
Keywords: arrestin essential; cell function; barr2; function ... See more keywords
Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008424
Abstract: Type 2 diabetes (T2D) has become a major health problem worldwide. Skeletal muscle (SKM) is the key tissue for whole-body glucose disposal and utilization. New drugs aimed at improving insulin sensitivity of SKM would greatly… read more here.
Keywords: skeletal muscle; barr2; barr1 barr2; mice ... See more keywords