Synthesis and Structure–Activity Studies of β-Barrel Assembly Machine Complex Inhibitor MRL-494
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DOI: 10.1021/acsinfecdis.2c00459
Abstract: In the hunt for new antibiotics with activity against Gram-negative pathogens, the outer membrane β-barrel assembly machine (BAM) complex has become an increasingly interesting target. The recently reported BAM complex inhibitor, MRL-494, was discovered via… read more here.
Keywords: structure; synthesis; barrel assembly; activity ... See more keywords
The sacrificial adaptor protein Skp functions to remove stalled substrates from the β-barrel assembly machine
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2114997119
Abstract: Significance The outer membrane (OM) of gram-negative bacteria acts as a robust permeability barrier to enable cell survival in a wide variety of harsh environments. Crucial to OM integrity are β-barrel outer membrane proteins (OMPs)… read more here.
Keywords: adaptor protein; sacrificial adaptor; bam complex; barrel ... See more keywords
Small Molecule Antibiotics Inhibit Distinct Stages of Bacterial Outer Membrane Protein Assembly
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DOI: 10.1128/mbio.02286-22
Abstract: There is a clear need to develop novel broad-spectrum antibiotics to address the global problem of antimicrobial resistance. Multiple compounds that have strong antibacterial activity have recently been described that appear to inhibit the activity… read more here.
Keywords: inhibit activity; outer membrane; barrel assembly; membrane ... See more keywords
The Escherichia coli Outer Membrane β-Barrel Assembly Machinery (BAM) Anchors the Peptidoglycan Layer by Spanning It with All Subunits
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DOI: 10.3390/ijms22041853
Abstract: Gram-negative bacteria possess a three-layered envelope composed of an inner membrane, surrounded by a peptidoglycan (PG) layer, enclosed by an outer membrane. The envelope ensures protection against diverse hostile milieus and offers an effective barrier… read more here.
Keywords: machinery; barrel assembly; layer; outer membrane ... See more keywords